Although well studied in vitro, the in vivo functions of G-quadruplexes (G4-DNA and G4-RNA) are only beginning to be defined. Recent studies have demonstrated enrichment for sequences with intramolecular G-quadruplex forming potential (QFP) in transcriptional promoters of humans, chickens and bacteria. Here we survey the yeast genome for QFP sequences and similarly find strong enrichment for th...

MOTIVATION A serious limitation in microarray analysis is the unreliability of the data generated from low signal intensities. Such data may produce erroneous gene expression ratios and cause unnecessary validation or post-analysis follow-up tasks. Therefore, the elimination of unreliable signal intensities will enhance reproducibility and reliability of gene expression ratios produced from mic...

The recent report of P2–Na2/3Mg0.28Mn0.72O2 (P2-NMM) demonstrated the possibility utilizing oxygen redox couple in a layered oxide cathode without need for alkali ions or vacancies transition metal layer. In this work, we synthesis new P2-type compound, Na2/3Mg1/4Mn7/12Co1/6O2 (P2-NMMC), which exhibits reversible specific capacities as high 173 mAh g?1 and an improvement first cycle voltage hys...

The new compounds T hC u^PO and ThCuAsO with ZrCuSiAs-type structure were pre­ pared in well crystallized form by chemical vapor transport reactions. Th2Ni3.A:P30 with a new structure type was obtained by reaction of T h 0 2 with the other elemental components in an alumina crucible at high temperatures. The crystal structures of the three compounds were determined from single-crystal X-ray dat...

Germ cells in most animals are connected by intercellular bridges, actin-based rings that form stable cytoplasmic connections between cells promoting communication and coordination [1]. Moreover, these connections are required for fertility [1, 2]. Intercellular bridges are proposed to arise from stabilization of the cytokinetic ring during incomplete cytokinesis [1]. Paradoxically, proteins th...

Closed-loop control is a promising deep brain stimulation (DBS) strategy that could be used to suppress high-amplitude epileptic activity. However, there are currently no analytical approaches to determine the stimulation parameters for effective and safe treatment protocols. Proportional-integral (PI) control is the most extensively used closed-loop control scheme in the field of control engin...

OBJECTIVE To compare the archwires inserted during the final stages of the orthodontic treatment with the generated moments at 0.018- and 0.022-inch brackets. MATERIALS AND METHODS The same bracket type, in terms of prescription, was evaluated in both slot dimensions. The brackets were bonded on two identical maxillary acrylic resin models, and each model was mounted on the orthodontic measur...

G-quadruplexes (G4) have been found increasing potential in applications, such as molecular therapeutics, diagnostics and sensing. Both Thioflavin T (ThT) and N-Methyl mesoporphyrin IX (NMM) become fluorescent in the presence of most G4, but thrombin-binding aptamer (TBA) has been reported as the only exception of the known G4-forming oligonucleotides when ThT is used as a high-throughput assay ...

Edgewise orthodontic treatment utilizes a force couple in order to achieve labial-lingual tooth angulation. Two self-ligating brackets (Damon Q and Speed) were examined across a range of clinically relevant torques in order to assess the loading and unloading curves and bracket deformation. A previously developed torquing and load measurement system was utilized to rotate a 0.199 × 0.25 in stai...

Neonatal meningococcal meningitis (NMM) is rare, although early onset and late onset forms of meningococcal sepsis in neonates have been reported. The outcome of meningococcal disease can be fatal and depends on the innate immune system, age, serogroups, pre-existing antibodies, and other unknown host factors. The presentation of NMM differs from that in children and adolescents and may present...