Transient receptor potential (TRP) ankyrin 1 (TRPA1) is a Ca(2+)-permeant, nonselective cationic channel. It is predominantly expressed in the C afferent sensory nerve fibers of trigeminal and dorsal root ganglion neurons and is highly coexpressed with the nociceptive ion channel transient receptor potential vanilloid 1 (TRPV1). Several physical and chemical stimuli have been shown to activate ...

Tetrasubstituted pyrrolidines representing analogs of homoproline were synthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagine and N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configuration at the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale.

Benign prostatic hyperplasia (BPH) is mainly caused by increased prostatic smooth muscle (SM) tone and volume. SM myosin (SMM) and non-muscle myosin (NMM) play important roles in mediating SM tone and cell proliferation, but these molecules have been less studied in the prostate. Rat prostate and cultured primary human prostate SM and epithelial cells were utilized. In vitro organ bath studies ...

The advancement of automotive technology is rapid in this era, as evidenced by the existence autopilot vehicles that have been developed a scientist. This progress balanced with knowledge continues to develop world education. Many prestigious competitions are held be venue for student creativity and research developing technology, one which Formula Student SAE. background study an engineered el...

Micro-cracks are known to greatly affect the mechanical properties of granite and subcritical crack growth (SCG) is considered be main mechanism brittle creep in rocks, including granite. Here, we provide new uniaxial compressive strength experiments for Lanhélin granite, a multi-crack numerical model explain experimental observations. We first thermally-stressed our samples create thermal micr...

Theoretical and numerical works indicate that a strong magnetic field should suppress fragmentation in dense cores. However, this has never been tested observationally relatively large sample of fragmenting massive Here we use the polarization data obtained Submillimeter Array Legacy Survey Zhang et al. to build 18 cores where both properties are studied uniform way. We measured level, Nmm, wit...