The results of studies the features phase composition, crystal and magnetic structure Bi-substituted barium hexaferrite BaFe12-xBixO19 (0.1≤ x≤ 1.2) by methods Mossbauer spectroscopy, X-ray analysis, as well image analysis scanning electron microscopy are presented. Samples hexaferrites - (where x=0.1; 0.3; 0.6; 0.9 were synthesized method solid-phase reactions with double annealing (at T=1100o...

Abstract Multi-analyte single cell technologies have potential to greatly accelerate antibody discovery by identifying antigen-specific B cells. Barcode Enabled Antigen Mapping (BEAM) provides a high-throughput, multimodal analysis of antigen-bound cells (BEAM-Ab) using 10x Genomics Chromium Single Cell Immune Profiling v2 Solution and novel computational approaches discover B-cell receptor (BC...

Leptospirosis is one of the most prevalent zoonotic diseases worldwide. Currently, multivalent whole-cell leptospiral vaccines can induce protection against leptospirosis. Therefore, preparation and formulation of new generations of vaccines that can stimulate long-term immunity for leptospirosis control are essential. The aim of this study was to prepare and characterize alginate microspheres ...

Objective(s): The aim of this study was to estimate effects of hyperbaric (HB) treatment by determination of CD15s and CD11b leukocyte proinflammatory markers expression.  In addition, this study describes changes in CD77 and CD34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. Materials and Methods:Expression of CD11b and CD...

Gluten sensitive enteropathy also known as Celiac disease, an autoimmune disorder which occurs in the presence of HLA DQ2 & DQ8 gene genetically susceptible individuals. Homoeopathy can direct treatment constitutionally and therapeutically. Gliadin a derivative gluten is modified by TTG seen antigen to Antigen presenting cells. The lead failure thrive.

in this study which has been carried out from 1996 until 1997 soluble latex agglutination antigen was prepared from L, donovani,sudan(s-1) by culturing in special media,harvesting,and later solubilizing by freezing and thawing.the antigen were futher prepared by high speed centrifugation.after measurement of the protein (lowry method) concentration of the antigen was set at 2.2 mg/ml,the antige...

Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit vaccines. GMMA have been observed induce a potent humoral immune response in preclinical and clinical studies. In addition, studies, it has found exploited as optimal antigen carriers both protein saccharide antigens, they able promote th...

Abstract Exhausted immune responses to chronic diseases represent a major challenge global health. To explore their cell fate and plasticity in exhaustion, we analyzed CD4+T cells mouse model with regulatable antigen presentation. When the are driven through effector phase, then exposed different levels of persistent antigen, they lose Th1 functions, upregulate exhaustion markers, resemble natu...

Abstract We identified the lowest composition necessary to generate a vaccination adjuvant that promotes Treg response following immunization in mice and named it “complete tolerogenic adjuvant.” This novel may allow us utilize well-established “antigen plus adjuvant” method of induce cell-mediated antigen-specific immunosuppression. The minimal is dexamethasone, rapamycin, monophosphoryl lipid...