A series of novel 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin- 5(4H)-yl)fluoroquinolone derivatives were designed, synthesized and characterized by 1H-NMR, MS and HRMS. These fluoroquinolones were evaluated for their in vitro antibacterial activity against representative Gram-positive and Gram-negative strains. Results reveal that most of the target compounds exhibit good growth i...

X-ray diffraction (XRD), EDAX, AC susceptibility and resistivity measurements has been used as characterization methods for the Bi-2223 monophase target with the starting stoichiometry Bil.8F%,.3Sr2Ca2C~3.3 a. Pressure parameter is playing an important role in obtaining good superconducting properties for this compound. Critical currents and activation energy has been calculated from susceptibi...

0304-4017/$ – see front matter doi:10.1016/j.vetpar.2005.07.009 Puerto Rico, U.S. Virgin Islands and Guam. Heartworm transmission has not been documented in Alaska and even with the importation of microfilaremic dogs, it is doubtful the climate this far north will permit maturation of infective larvae. Relocation of infected, microfilaremic dogs appears to be the most important factor contribut...

Abstract Background Currently, thoracoscopic lobectomy is widely used in clinical practice, and postoperative placement of ultrafine drainage tube has advantages reducing pain accelerating recovery patients. This study aimed to investigate the feasibility safety 8F chest after its superiority over traditional 24F tube. Methods A retrospective data analysis was conducted 169 patients who underwe...

PURPOSE The purpose of this study was to investigate the function of Zinc finger protein 488 (ZNF488) in nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS The endogenous expression of ZNF488 in NPC tissues, normal nasopharyngeal epithelium tissues and NPC cell lines were detected by quantitative reverse transcription polymerase chain reaction. ZNF488 over-expressing and knock-down NPC cel...

We show that, as a consequence of fixing f π = 93 MeV: (1) a bound state pole in the the J P = 1 − scattering amplitude of the ENJL model exists for arbitrarily weak (positive) vector coupling G 2 so long as the constituent quark mass is sufficiently large; (2) there is a bound state for any quark mass when G 2 ≥ 0.6/(8f 2 π); (3) this bound state becomes massless at G 2 = 1/(8f 2 π) and a tach...

A series of novel coumarin-containing α-aminophosphonates were synthesized and evaluated for their antitumor activities against Human colorectal (HCT-116), human nasopharyngeal carcinoma (human KB) and human lung adenocarcinoma (MGC-803) cell lines in vitro. Compared with 7-hydroxy-4-methylcoumarin (4-MU), most of the derivatives showed an improved antitumor activity. Compound 8j (diethyl 1-(3-...