The present study investigated the effects of microRNA-124-3p (miR-124-3p) expression on nasopharyngeal carcinoma (NPC) cells and its relevant mechanism. A total of 90 NPC tissues and 85 postnasal catarrh tissues were collected. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect tissue samples and expression of miR-124-3p in CNE1, CNE2, SUNE1, H0NE1, 5-8F, 6-10B and C...

The present work highlights the synthesis and effect of introducing substituents on nitrogen at position -1 five 2-benzylthiopyrimidine derivatives (6a-e). compounds (6a-e) were obtained by condensation 2-thiopyrimidines (4) with benzyl halides in presence a base. As for N-alkylated/arylated-2thiobenzylpyrimidines (8a-k), they nucleophilic substitution reaction basic medium. All synthesized cha...

A series of (κ2-N,O)-salicylaldiminato Ni(II)-methyl pyridine complexes 7-pyr and 8-pyr derived from 3,5-diiodosalicyaldehyde (3a) and 3-(9-anthryl)salicylaldehyde (3b), and terphenylamines 2,6-(3,5R-4-R′-C6H2)2C6H3-NH2 (4a, R ) CF3, R′ ) H; 4b, R ) tBu, R′ ) H; 4c, R ) tBu, R′ ) OH; 4d, R ) Me, R′ ) H; 4e, R ) Me, R′ ) MeO; 4f, R ) MeO, R′ ) H; 4g, R ) MeO, R′ ) MeO), was prepared by reaction ...

Relatively weak tumor affinities and short retention time in vivo hinder the application of targeting peptides in tumor molecular imaging. Multivalent strategies based on various scaffolds have been utilized to improve the ability of peptide-receptor binding or extend the clearance time of peptide-based probes. Here, we use a tetrameric far-red fluorescent protein (tfRFP) as a scaffold to creat...

5-Formylcytosine (5fC) and 5-formyluracil (5fU) are natural nucleobase modifications that are generated by oxidative modification of 5-methylcytosine and thymine (or 5-methyluracil). Herein, we describe chemoselective labeling of 5-formylpyrimidine nucleotides in DNA and RNA by fluorogenic aldol-type condensation reactions with 2,3,3-trimethylindole derivatives. Mild and specific reaction condi...

U16-binding protein 4 (ULBP4), a human ligand for natural killer group 2, member D (NKG2D) receptor on NK cells and subsets of T cells, is thought to activate anticancer immune responses. However, the expression pattern and prognostic effect of ULBP4 in nasopharyngeal carcinoma (NPC) has not been investigated. We first compared ULBP4 expression between archival 15 NPC tissues and 8 normal nasop...