Abstract Background The skin is both a target and potential conduit for the delivery of drugs, but its cornified cell layer resists penetration by most molecules. This study investigated superparamagnetic iron oxide nanoparticles to facilitate transdermal anticancer agents. Results Chemotherapeutic cancer drugs were applied with or without hairless mice, their ability penetrate was assessed usi...

Introdução: Agentes quimioterápicos frequentemente induzem a um balanço nitrogenado negativo e perda de peso, contribuindo para desenvolvimento progressão da caquexia. Objetivo: Avaliar peso em pacientes oncológicos tratados com diferentes protocolos quimioterápicos. Metodologia: Selecionamos 16 (parecer comitê ética 4.192.874), ambos os sexos (n=11 masculino n= 5 feminino), idades entre 50 80 ...

We investigated the effects of combined treatment with 5-fluorouracil and apigenin on proliferation and apoptosis, as well as the underlying mechanism, in human breast cancer MDA-MB-453 cells. The MDA-MB-453 cells, which have been shown to overexpress ErbB2, were resistant to 5-fluorouracil; 5-fluorouracil exhibited a small dose-dependent anti-proliferative effect, with an IC50 of 90 microM. In...

OBJECTIVE Owing to the risks of serious and sustained toxicity, anticancer drugs such as cisplatin and irinotecan cannot be readily administered to patients with gastric cancer and severe peritoneal metastasis. Therefore, a standard chemotherapy regimen has yet to be established for these types of patients. This randomized study investigated the utility of sequential methotrexate and 5-fluorour...

Advanced cancer responds clinically to combined therapy with recombinant interferon-alpha and 5-fluorouracil. Although the two agents may interact in the biosynthetic pathway for thymidine, we investigated, as an alternative mechanism, the regulation of susceptibility of the A375 human melanoma to natural killers activated by interferon. A375 were preincubated with 5-fluorouracil, interferon, o...

several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-fu related toxicity. the aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-fu in rabbits, mice and dogs. it was further aimed to determine its route related toxicity in rabbits.    plasma concentration of both 5-fu and its metabolite 5-f...