An alcoholic extract of Artemisia dracunculus L (PMI 5011) has been shown to decrease glucose and improve insulin levels in animal models, suggesting an ability to enhance insulin sensitivity. We sought to assess the cellular mechanism by which this botanical affects carbohydrate metabolism in primary human skeletal muscle culture. We measured basal and insulin-stimulated glucose uptake, glycog...

Ectopic lipids in peripheral tissues have been implicated in attenuating insulin action in vivo. The botanical extract of Artemisia dracunculus L. (PMI 5011) improves insulin action, yet the precise mechanism is not known. We sought to determine whether the mechanism by which PMI 5011 improves insulin signaling is through regulation of lipid metabolism. After differentiation, cells were separat...

Continuous Transversus Abdominis Plane (TAP) Block and Intraoperative Coeliac Plexus Block (CPB) for Post-Operative Analgesia Following Laparotomy: Two Case Reports Vasanth Rao Kadam, and George Kiroff Clinical Senior Lecturer, The University of Adelaide, Acute Care Medicine, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville, SA, 5011. Australia Division of Surgery, Hepatobiliary Unit,...

1Department of Nephrology and Transplantation Services, The Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia 5011, 2Department of Medicine, University of Adelaide, North Terrace, Adelaide, South Australia 5000, 3ANZDATA Registry, The Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia 5011 and 4Hyperbaric Unit, The Royal Adelaide Hospital, Adel...

We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabeti...

Artemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. C57Bl6/J mice fed high-fat diet for 16 weeks developed o...

OBJECTIVE The agouti-related protein (Agrp) is a powerful orexigenic peptide, but little is known about its transcriptional regulation. The objective of this study was to determine molecular mechanisms for the activation of hypothalamic Agrp and identify compounds that stimulate appetite. RESEARCH DESIGN AND METHODS We used promoter analyses methods, hypothalamic cell culture and transfection...

In this study, urease production was investigated among thirteen strains of Aspergillus niger seven strains isolated from soils of Semnan province in Iran and six strains obtained from Persian Type Culture Collection (PTCC). The enzyme production was screened in two submerged media quantitatively. The registered PTCC 5011 and the native S31 strains showed more urease production than the other e...

Department of Clinical Pharmacology, The Queen Elizabeth Hospital, Woodville, South Australia, Australia, 5011 (ISW, RGM, BCS); Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, South Australia, Australia, 5000 (RGM, BCS); School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia, 5000 (ISW, LRB, AME). DMD ...