نتایج جستجو برای: 5’

تعداد نتایج: 1215766  

Journal: :Molecular bioSystems 2014
Debin Ji Krystal Lin Jikui Song Yinsheng Wang

We investigated systematically the effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation in synthetic duplex DNA. We found that the replacement of 5-methylcytosine at a CpG site with a 5-hydroxymethylcytosine, 5-formylcytosine, 5-carboxylcytosine or 5-hydroxymethyluracil resulted in altered methylation of cytosine at both the opposite a...

Journal: :Rocky Mountain Journal of Mathematics 1999

2016
Jeffrey A. Gross Corina Nagy Li Lin Éric Bonneil Marissa Maheu Pierre Thibault Naguib Mechawar Peng Jin Gustavo Turecki

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

2012
Chun-Xiao Song Chengqi Yi Chuan He

Nucleotide variants, especially those related to epigenetic functions, provide critical regulatory information beyond simple genomic sequence, and they define cell status in higher organisms. 5-Methylcytosine, which is found in DNA, was until recently the only nucleotide variant studied in terms of epigenetics in eukaryotes. However, 5-methylcytosine has turned out to be just one component of a...

2016
Thuy T M Ngo Jejoong Yoo Qing Dai Qiucen Zhang Chuan He Aleksei Aksimentiev Taekjip Ha

Cytosine can undergo modifications, forming 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). Despite their importance as epigenetic markers and as central players in cellular processes, it is not well understood how these modifications influence physical properties of DNA and chromatin. Here we report a co...

2016
Hao Lian Wen-Bin Li Wei-Lin Jin

The Ten-eleven translocation (TET) proteins have been recently identified as critical regulators in epigenetic modification, especially in the methylation of cytosine in DNA. TET-mediated DNA oxidation plays prominent roles in a wide variety of physiological and pathological processes, especially in tumor and neural development. TET proteins execute stepwise enzymatic conversion of 5-methylcyto...

2015
Robyn E. Hardisty Fumiko Kawasaki Aleksandr B. Sahakyan Shankar Balasubramanian

We present a chemical method to selectively tag and enrich thymine modifications, 5-formyluracil (5-fU) and 5-hydroxymethyluracil (5-hmU), found naturally in DNA. Inherent reactivity differences have enabled us to tag 5-fU chemoselectively over its C modification counterpart, 5-formylcytosine (5-fC). We rationalized the enhanced reactivity of 5-fU compared to 5-fC via ab initio quantum mechanic...

Journal: :Angewandte Chemie 2015
Mirko Wagner Jessica Steinbacher Theo F J Kraus Stylianos Michalakis Benjamin Hackner Toni Pfaffeneder Arshan Perera Markus Müller Armin Giese Hans A Kretzschmar Thomas Carell

The absolute levels of 5-hydroxymethylcytosine (hmC) and 5-methylcytosine (mC) in human brain tissues at various ages were determined. Additionally, absolute levels of 5-formylcytosine (fC) in adult individuals and cytosine modification levels in sorted neurons were quantified. These data were compared with age-related fC, hmC, and mC levels in mouse brain samples. For hmC, an initial steady in...

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