In the title compound, C16H10O8·H2O, the dihedral angle between the benzene rings is 71.59 (8)°. The COOH groups make dihedral angles of 10.3 (2), 30.8 (2), 11.3 (2) and 42.3 (2)° with their attached rings. In the crystal, O-H⋯O hydrogen bonds link the components forming a three-dimensional supra-molecular network.

The title compound, C(11)H(14)O(3), is a multiple-substituted derivative of benzoic acid. Intra-cyclic C-C-C angles span a range of 117.16 (19)-122.32 (19)°. Apart from intra-molecular hydrogen bonds between hydroxyl and carboxyl groups, inter-molecular hydrogen bonds are present in the crystal structure, the latter ones giving rise to centrosymmetric carb-oxy-lic acid dimers.

The title compound, C(10)H(7)FO(4), is an inter-mediate in the synthesis of the drug Fidarestat, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione. The di-hydro-pyran-one ring adopts an envelope conformation with the asymmetric C atom in the flap position. In the crystal, the mol-ecules are linked into zigzag chains along [100] by O-H⋯O hydrogen bonds and C-H⋯π inter-...

In the title compound, C(9)H(6)FNO(2), all the non-H atoms are approximately coplanar, the carb-oxy O atoms deviating by 0.0809 and -0.1279 Å from the indole plane. In the crystal, O-H⋯O hydrogen bonds link the mol-ecules into dimers which are linked via N-H⋯O hydrogen bonds and π-π inter-actions [centroid-centroid distance = 3.680 (2) Å].

In the title mol-ecule, C(9)H(6)BrNO(2), the dihedral angle between the -COOH group and the ring system is 6 (4)°. In the crystal, pairs of O-H⋯O hydrogen bonds link the mol-ecules into inversion dimers and these dimers are connected via N-H⋯O hydrogen bonds to form layers parallel to the (-101) plane.

The structure of the title compound, C(6)H(7)N(3)O(2), is of inter-est with respect to radiopharmacueticals. The crystal packing is characterized by N-H⋯O and O-H⋯N hydrogen bonds, which form a three-dimensional network. The molecule is planar except for one of the amine H atoms.

In the title compound, C13H8Cl3NO4S, the aromatic rings are oriented at a dihedral angle of 68.94 (1)° and the mol-ecule adopts a V-shape. An intra-molecular N-H⋯O inter-action generates a six-membered S(6) ring motif. In the crystal, pairs of O-H⋯O hydrogen bonds involving the carb-oxy group link the mol-ecules into inversion dimers with an R 2 (2)(8) motif. N-H⋯O and non-classical C-H⋯O inter...

6-Aminohexanoic acid is a potent antifibrinolytic agent with the ability to retard dissolution of fibrin clots. The corneal penetration of 6-aminohexanoic acid was measured to determine if therapeutic levels of the drug could be maintained in the anterior chamber by topical administration. The conjunctival sac to anterior chamber transfer coefficient was found to be 1.51 X 10-4 +/- 0.20 X 10-4 ...

Erythromycin A (1), a well-established macrolide antibiotic, is unstable under acidic conditions. When administered orally, 1 is in equilibrium with its 8,9-anhydro-6,9-hemiketal and is simultaneously converted directly to the antibacterially inactive 6,9:9,12-spiroketal1}. A number of research groups in recent years have prepared new derivatives of erythromycin A by modification of the functio...