Among the L-type calcium channel blockers (CCBs), particularly dihydropyridines like nifedipine [1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester], a common adverse effect is vasodilatory edema. Newer CCBs, such as the T- and L-type CCB, mibefradil [(1S,2S)-2-[2[[3-(2-benzimidazolylpropyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthy...

All non-H atoms of the title compound, C(7)H(7)NO(2), are nearly coplaner, the r.m.s. deviation being 0.0087 Å. In the crystal, the partially overlapped arrangement and the face-to-face distance of 3.466 (17) Å between parallel pyridine rings of neighboring mol-ecules indicates the existence of π-π stacking. Inter-molecular O-H⋯N hydrogen bonding and weak C-H⋯O hydrogen bonding are present in t...

Three aromatic oligoamides have been prepared that have alternating 1,6-diaminopyridine and 1,6-pyridinedicarboxylic acid units at the center of the sequence and two 8-amino-2-quinolinecarboxylic acid units at each extremity. The three oligomers differ in the number--3, 5, or 7-of pyridine units in the sequence. They were designed to adopt helically folded conformations in solution and in the s...

Although it is well established that paramagnetic NMR spectroscopy is a powerful tool to derive structural information, the methodology is still not yet universally applied to paramagnetic small molecule complexes. In this paper paramagnetic H NMR spectroscopy is investigated as a convenient method for the experimental inorganic chemist to elucidate solution structures and speciation of small m...