Symmetry is as simple or as complicated as we are ready to absorb it in everything around us. From flowers to bridges, buildings, coke machines, and snowflakes; from molecules to walnuts, fences, pine cones, and sunflowers; from music to children's drawings; from hubcaps to bank logos, propellers, wallpaper decorations, and pavements, we recognize it if we walk around with open eyes and an open...

In South Carolina, the ES&S voting systems include iVotronic direct recording electronic touch-screen voting machines, a Unity computer for each county, and Model 650 and Model 100 optical scan machines. A major difference between machines used in South Carolina and those tested in Ohio is that iVotronics in Ohio have an add-on paper tape, where the vote cast is recorded for use in a recount. T...

P-glycoprotein (P-gp) and CYP3A (cytochrome P450 3A, generally; Cyp3a, rodent enzyme) in the intestine can attenuate absorption of orally administered drugs. While some suggest that P-gp enhances intestinal metabolism by CYP3A/Cyp3a during absorption of a dual substrate, others suggest that P-gp reduces the metabolism in the intestine when substrates are at subsaturating concentrations. Hence, ...

Recent analyses demonstrated that metabolites are unlikely to contribute significantly to clinical inhibition of cytochrome P450 (P450)– mediated drug metabolism, and that only ∼2% of this type of drug interaction could not be predicted from the parent drug alone. Due to generally increased polarity and decreased permeability, metabolites are less likely to interact with P450s, but their dispos...

Reflectance spectra from 400 to 750 nm were measured in Lake Kinneret, when low phytoplankton stock prevailed, with chlorophyll concentrations from 3.1 to 7.3 pg/l. Algorithms for estimation of chlorophyll (CHL) concentration were devised using reflectances in the blue and green region of the spectrum and natural solar induced fluorescence. The fluorescence was calculated either from the reflec...

Ciprofloxacin, a quinolone with good intracellular penetration may possibly be used for treatment of melioidosis caused by Burkholderia pseudomallei, but problems with resistance may be encountered. Amino acid substitutions in gyrA/gyrB have given rise to fluoroquinolone resistance in various microorganisms. Using published primers for gyrA and gyrB, PCR was performed on 11 isolates of B. pseud...

Direct detection of (13)C can be advantageous when studying uniformly enriched proteins, in particular for paramagnetic proteins or when hydrogen exchange with solvent is fast. A scheme recently introduced for long-observation-window band-selective homonuclear decoupling in solid state NMR, LOW-BASHD (Struppe et al. in J Magn Reson 236:89-94, 2013) is shown to be effective for (13)C(α) decoupli...