Avian eggshells are variedly coloured, yet only two pigments, biliverdin and protoporphyrin IX, are known to contribute to the dramatic diversity of their colours. By contrast, the contributions of structural or other chemical components of the eggshell are poorly understood. For example, unpigmented eggshells, which appear white to the human eye, vary in their ultraviolet (UV) reflectance, whi...

Abstract Aim Electronic discharge summaries (EDS) in General Surgery were found to be lacking adequate clinical information. The Professional Records Standards Body (PRSB) released guidance, endorsed by NICE, with the information required an electronic summary. aim of study was monitor and record how many EDS’s have been completed all relevant/required sections completed. Method A retrospective...

Tofacitinib is a novel, oral Janus kinase inhibitor. The objectives of this study were to summarize the pharmacokinetics and metabolism of tofacitinib in humans, including clearance mechanisms. Following administration of a single 50-mg C-labeled tofacitinib dose to healthy male subjects, the mean (standard deviation) total percentage of administered radioactive dose recovered was 93.9% (63.6),...

Malaria causes high global mortality and morbidity annually. Plasmodium knowlesi has been recognised as the fifth human Plasmodium sp. and its infection is widely distributed in Southeast Asia. Merozoite surface protein-119 (MSP-119) appears as a potential candidate for malaria blood stage vaccine as it could induce protective immunity. In this study, codon optimized P. knowlesi MSP-119 (pkMSP-...

We present a study of the extreme O-type supergiant He 3–759 using new high-resolution FEROS data, revealing that it is a near spectroscopic twin of HD 151804 (O8 Iaf). We investigate the extinction towards He 3–759 using a variety of methods, revealing AV ∼ 4.7 m . If we assume He 3–759 has an identical absolute K-band magnitude to HD 151804 we find that it lies in the SagittariusCarina spiral...

We consider the single production of charged Higgs bosons H of the twoHiggs-doublet model in eγ collisions through the production subprocess eγ → νH. As the production rate is governed by the size of the loop-induced HWγ coupling, the cross section can only be substantial for smaller values of tanβ, tanβ . 1, where the top-bottom loop contribution is enhanced. In this case, however, the natural...

Two newly identified, overlapping (1 bp) glucocorticoid response elements (GREs) at -759 and -773 bp in the promoter of the rat phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) gene are primarily responsible for its glucocorticoid sensitivity, rather than the originally identified -533-bp GRE. A dose-dependent increase in PNMT promoter activity was observed in RS1 cells transfected wi...

BACKGROUND The efficacy, acceptability and tolerability of the new oral phosphate binder Lenziaren® (SBR759) were evaluated in a randomized parallel-group design study in 36 healthy cats (n = 6 per group). Five groups were fed once daily with a commercial diet containing 0.2% phosphorus ("standard diet") into which was mixed Lenziaren® at 0.25, 0.5, 1.0 or 2.0 g/day or no treatment (control gro...