13C cross-polarization magic angle spinning (CP/MAS) NMR data for 2,2,5,7,8-pentamethylchroman-6-ol (2), 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox c) (3) and its acetate (4), 2-methoxy-2,2,5,7,8-pentamethylchroman-6-ol (5), 2-hydroxy-2,2,5,7,8-pentamethylchroman-6-ol (6) and 2,2,5,7,8-pentamethylchroman (7) are reported. A deshielding of 7.7 ppm for the carboxylic carbon wa...

[structure: see text] Pyridoxamine is known to be an effective inhibitor of both advanced glycation (AGE) and advanced lipoxidation (ALE) end products. The synthesis of a novel multifunctional AGE and ALE inhibitor, 6-dimethylaminopyridoxamine (dmaPM, 11) is described. The 6-dimethylamino substituent increases the radical trapping ability of pyridoxamine's phenolic group. Results obtained durin...

A modified in vitro lipid peroxidation inhibition assay was used to guide the fractionation and the isolation of antioxidative principles of Fnnish pine bark extract. This approach yielded 3,4-dihydroxybenzoic acid (protocatechuic acid) and taxifolin-3-O-beta-glucopyranoside as major antioxidative compounds from the plant material. The structural elucidation of these compounds was undertaken wi...

This study was conducted to evaluate the radical scavenging capacities of extracts and preparations from a Lavandula vera MM plant cell culture with different rosmarinic acid content and to compare them with pure rosmarinic and caffeic acids as well. The methods, which were used are superoxide anion and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals scavenging a...

In this study, one novel N-pyrrolyl carboxylic acid (3), the corresponding hydrazide (5), and four new hydrazide-hydrazones (5a-d) bearing electron donating moieties were designed, synthesized, fully elucidated by 1H NMR, FT-IR, HRMS. The produced in five steps, which optimized applying microwave heating. microwave-assisted synthesis significantly decreased reaction times increased yields of ti...

Free radicals and reactive oxygen species (ROS) have been implicated in contributing to the processes of aging and disease. In an effort to combat free radical activity, scientists are studying the effects of increasing individuals' antioxidant levels through diet and dietary supplements. Honey appears to act as an antioxidant in more ways than one. In the body, honey can mop up free radicals a...

Abstract Coumarin and its nitrogen analogue 1-aza coumarin are a class of lactones lactams, respectively, which indispensable heterocyclic units to both chemists biochemists. 1-Aza derivatives, ultimately metabolize as the corresponding 8-hydroxy coumarins in biological system therefore found be very good anti-inflammatory, anti-cancer, analgesic agents. A series hybrid substituted azacoumarin-...

Background: The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion ex...

Abstract Growth of bionanotechnology requires functional materials, which can lower the costs and be modified to specific reaction. Conjugations nanoparticles enzymes form efficient products multi-material enzyme-nanocomplexes, controlled from synthesis application provide predicted results. Multimetallic nanooxides ZnO–CuO, ZnO–MnO, ZnO–MnO–CuO were obtained by precipitation method with sonica...