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The evaluation of the outcome of health services technologies is a requirement for their efficient provision in clinical practice. The most reliable evidence for treatment efficacy comes from randomized trials. Randomized trials in general practice pose particular methodological and practical difficulties. In this paper, we discuss how best to plan and manage a clinical trial in this setting. W...

Esculetin (6,7-dihydroxycoumarin, ET) and 4-methylesculetin (6,7dihydroxy-4-methylcoumarin, 4-ME) are typical coumarin derivatives that are attracting considerable attention because of their wide spectrum of biologic activities, but their metabolism remains unknown. This study aimed to elucidate the in vitro UDPglucuronosyltransferase (UGT) metabolism characteristics of ET and 4-ME. 7-O-monoglu...

Intensive management of grass seed fields in the poorly drained soils of the Willamette Valley, Oregon, has prompted concern in the capacity of these landscapes and their associated minimally managed riparian areas to process and retain fertilizer N. Our goal was to determine the extent of N losses and effectiveness of a riparian area and an adjacent perennial ryegrass seed field to retain N. T...

Proteinuria is an important cause of tubulointerstitial damage. Antiproteinuric interventions are not always successful, and residual proteinuria often leads to renal failure. This indicates the need for additional treatment modalities by targeting the harmful downstream consequences of proteinuria. We previously showed that proteinuria triggers renal lymphangiogenesis before the onset of inter...

Muscle is an integrated tissue composed of distinct cell types and extracellular matrix. While much emphasis has been placed on the factors required for the specification of the cells that comprise muscle, little is known about the crosstalk between them that enables the development of a patterned and functional tissue.We find in mice that deletion of lysyl oxidase (Lox), an extracellular enzym...

MICHAEL J. LENOX Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-8025 Fax: (919) 681-6244 [email protected] SCOTT F. ROCKART Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7998 Fax: (919) 681-6244 [email protected] ARIE Y. LEWIN Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7832 Fa...

MICHAEL J. LENOX Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-8025 Fax: (919) 681-6244 [email protected] SCOTT F. ROCKART Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7998 Fax: (919) 681-6244 [email protected] ARIE Y. LEWIN Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7832 Fa...

MICHAEL J. LENOX Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-8025 Fax: (919) 681-6244 [email protected] SCOTT F. ROCKART Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7998 Fax: (919) 681-6244 [email protected] ARIE Y. LEWIN Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7832 Fa...