Brown spot disease caused by Alternaria alternata (Fr.: Fr.) Keissl is a serious problem forproduction of tangerines and tangerine hybrids in Iran. The Tangerine pathotype causes brownspot disease on young leaves and immature fruits of limited varieties of mandarins and tangerines(Citrus. reticulata Blanco). Specificity in the interaction between tangerine and the pathogen isdetermined by a hos...

brown spot disease caused by alternaria alternata (fr.: fr.) keissl is a serious problem forproduction of tangerines and tangerine hybrids in iran. the tangerine pathotype causes brownspot disease on young leaves and immature fruits of limited varieties of mandarins and tangerines(citrus. reticulata blanco). specificity in the interaction between tangerine and the pathogen isdetermined by a hos...

Alternaria brown spot disease is caused by the alternata tangerine pathotype, which relies on ACT-toxin for infection. At present, all identified biosynthesis-related genes are multi-copy genes. In this study, we summarized advances in important host-specific toxins (HSTs), and listed key required pathogenicity of A. pathotype. Toxin virulence test results revealed that different citrus species...

certain strains of staphylococcus aureus produce a toxin which cause epidermal exfoliation within 18 hours after direct subcutaneous or intraperitoneal injection into newborn mice. the extracellular product responsible for exfoliation is termed exfoliative toxin (et). in the present studies a modified assay system has been developed for detection of exfoliativeactivity in toxin negative strains...

Bordetella pertussis, the whooping cough pathogen, secretes several virulence factors among which adenylate cyclase toxin (ACT) is essential for establishment of the disease in the respiratory tract. ACT weakens host defenses by suppressing important bactericidal activities of the phagocytic cells. Up to now, it was believed that cell intoxication by ACT was a consequence of the accumulation of...

Bordetella pertussis, the bacterium that causes whooping cough, secretes an adenylate cyclase toxin (ACT) that must be post-translationally palmitoylated in the bacterium cytosol to be active. The toxin targets phagocytes expressing the CD11b/CD18 integrin receptor. It delivers a catalytic adenylate cyclase domain into the target cell cytosol producing a rapid increase of intracellular cAMP con...

Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters human phagocytes and catalyzes the unregulated formation of cAMP, hampering important bactericidal functions of these immune cells that eventually cause cell death by apoptosis and/or necrosis. A...

The adenylate cyclase toxin (ACT) of Bordetella pertussis internalizes its catalytic domain into target cells. ACT can function as a tool for delivering foreign protein antigen moieties into immune effector cells to induce a cytotoxic T lymphocyte response. In this study, we replaced the catalytic domain of ACT with an enzymatically active protein moiety, the S1 (ADP-ribosyltransferase) subunit...