BACKGROUND Acute generalized exanthematous pustulosis (AGEP) represents a severe, acute, pustular skin reaction that is most often induced by drugs. AGEP can be difficult to differentiate from generalized pustular psoriasis (GPP) both clinically and histopathologically. We present a systematic description of the histopathological spectrum of AGEP and GPP with a focus on discriminating features....

AGEP: Acute generalized exanthematous pustulosis EBV: Epstein-Barr virus A cute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous reaction characterized by the acute onset of generalized nonfollicular sterile pustules arising on an edematous erythema. The eruption is usually associated with fever and neutrophilic leukocytosis. Although AGEP is precipitated by drugs in most ...

Acute generalized exanthematous pustulosis (AGEP) is manifested by rapid development of many sterile, nonfollicular pustules on a background of edematous erythema. More than 90 percent of AGEP are induced by medication, mostly antibiotics. Drug patch test can be helpful in the diagnosis of AGEP. This paper reports the first case of celecoxib-induced AGEP confirmed by patch test in Korean litera...

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse reaction characterized by acute sterile pustular eruptions, mostly induced by medications. Antibiotics are the most commonly implicated drugs; however, there have only been two previous reports of vancomycin-induced AGEP in the literature. In this case, we present the clinical course of a 56-year-old man who was admit...

BACKGROUND Patch tests are considered safe but adverse reactions have been reported. OBSERVATIONS A case of acute generalized exanthematous pustulosis (AGEP) provoked by a patch test with acetaminophen is described. Of special interest are the negative patch test results obtained with the offending drug. The case is discussed against the background of the putative mechanisms of AGEP and the r...

Background. Acute generalized exanthematous pustulosis (AGEP) is an acute pustular eruption characterized by widespread nonfollicular sterile pustules. The aim of this study is to characterize the etiology, clinical features, laboratory findings, management, and outcome of patients with AGEP in Asians. Patient/Methods. A retrospective analysis was performed on patient who presented with AGEP be...

other laboratory values were unremarkable. A biopsy specimen was not taken. The patient was treated with 0.05% topical desonide lotion for the rash, the antihistamines hydroxyzine and levocetirizine for the pruritus, and empirical antibiotics for possible systemic infection. On day 4, his fever had subsided completely and all blood culture results were negative. On day 6, generalized cutaneous ...

Duloxetine is a serotonin and norepinephrine reuptake inhibitor. Some rare duloxetine-induced hypersensitivity skin reactions have been reported. We report case of acute generalized exanthematous pustulosis potentially induced by duloxetine. Skin pustules appeared 8 days after the introduction Treatment with topical clobetasol propionate led to gradual remission lesions. As there are no cases p...

Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases because of its anti-inflammatory and immunosuppressive effects, is an uncommon ca...

Acute Generalized Exanthematous Pustulosis (AGEP) is a dermatosis characterised by an acute episode of appearance of sub-corneal sterile pustules over erythematous-edematous skin. AGEP is often associated with systemic symptoms such as high grade fever and is usually considered to be an adverse drug reaction, although a viral etiology is sometimes implicated. Here we report a case of AGEP follo...