Psoriasis is a chronic hyperproliferative skin disease, which affects approximately 2% to 4% of the general population. This immune-mediated disorder is characterized by erythematous scaling plaques ranging extensively in size on the scalp, elbows, knee, and other surfaces of the skin (1). Importantly, genetic, immunohistochemical, and pharmacologic investigations support a prominent role for n...

The synthesis of 1,5-dihydroxy-9,10-anthraquinone (17); (1,5-DHA) was accomplished during, attempts towards the synthesis one of its derivatives called anthralin (1,8-dihydroxy-9-anthrone) which is known as an antipsoriasis drug since 1916 [1]. This work is a new reigiospecilic preparation of 1,5-DHA based on Friedel-Crafts reaction starting from 1,4-dimethoxybenzene. This synthetic route, ...

the synthesis of 1,5-dihydroxy-9,10-anthraquinone (17); (1,5-dha) was accomplished during, attempts towards the synthesis one of its derivatives called anthralin (1,8-dihydroxy-9-anthrone) which is known as an antipsoriasis drug since 1916 [1]. this work is a new reigiospecilic preparation of 1,5-dha based on friedel-crafts reaction starting from 1,4-dimethoxybenzene. this synthetic route, in a...

Chronic plaque psoriasis affects more than 2% of world population, has a chronic recurrent behavior, gives a heavy burden to the patients' quality of life, and hence remains a huge medical and social problem. The clinical results of conventional therapies of psoriasis are not satisfactory. According to the current knowledge of the molecular and cellular basis of psoriasis, it is defined as an i...

The hybrid system based on nanoparticles (NPs) self-assembled by the conjugations of hyaluronic acid with cholesterol (HA-Chol NPs) combined with nicotinamide (NIC) for tacrolimus (FK506), ie, FK506 NPs-NIC, has been confirmed to exhibit a significant synergistic effect on FK506 permeation through and into intact skin; thus, it may be a promising approach for FK506 to effectively treat skin dis...

Although the management options for psoriasis have progressed with use of systemic agents, there are few efficacious nonsteroidal topical therapies patients limited or lower grade disease. The effects allopurinol (Allo) and glutathione (GSH) were examined in two different vitro models psoriasis. In first model, human immortalized keratinocytes (HaCaT) treated M5 cocktail (IL-17A, IL-22, oncosta...

Psoriasis is an incurable, chronic, recurrent immune-mediated in?ammatory dermatosis characterized by epidermal hyperplasia and excessive in?ltration of cells into the dermis neovascularization. The study aimed to provide a systematic review on in vitro, vivo, clinical studies support traditional uses herbal medicine for psoriasis treatment.  was performed combining three databases, that i...