acute lymphoblastic leukemia (all) is one of the most prevalent hematologic malignancies in children. although the cure rate of all has improved over the past decades, the most important reason for all treatment failure is multidrug resistance (mdr) phenomenon. the current study aims to explain the mechanisms involved in multidrug resistance of childhood all, and introduces atp-binding cassette...

Abstract The plant hormone auxin is distributed in the by a sophisticated network of importers and exporters, including members ABCB subclass ATP-binding cassette (ABC) transporters. ABCB-mediated transport controlled Twisted Dwarf1, member FK506-binding protein (FKBP) family. Here, we summarize current knowledge on ABC transporter regulation FKBPs, which seems to be conserved over kingdoms sub...

Abstract The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little known about its structure and drug-binding sites. In this study, we generated an atomistic model full-length ABCB5 with highest quality using X-ray crystal mouse ABCB1 (Pgp1), close homologue well-studied fam...

results a significant increase in blood abca1 (ex group p < 0.002, t = - 9.876) and apo a-i (ex group p < 0.05, t = 2.76) gene expression was shown following the 12 weeks of training. plasma high-density lipoprotein-cholesterol (hdl-c) concentration increased (p < 0.001, t = 4.90 respectively) while plasma low-density lipoprotein-cholesterol (ldl-c) concentration decreased (p < 0.001, t = 4.27)...

Abstract Tripartite efflux pumps built around ATP-binding cassette (ABC) transporters are membrane protein machineries that perform vectorial export of a large variety drugs and virulence factors from Gram negative bacteria, using ATP-hydrolysis as energy source. Determining the number ATP molecules consumed per transport cycle is essential to understanding efficiency substrate transport. Using...

Root-synthesized cytokinins regulate the growth, development, and stress responses of aboveground tissues follow transport route via xylem tissue. Arabidopsis ATP-binding cassette (ABC) transporter G family member 14 (AtABCG14) is involved in loading root-synthesized cytokinins. However, phloem unloading cytokinin shoot distribution have remained elusive. The recent study by Zhao et al., (2021)...

Acute lymphoblastic leukemia (ALL) is one of the most prevalent hematologic malignancies in children. Although the cure rate of ALL has improved over the past decades, the most important reason for ALL treatment failure is multidrug resistance (MDR) phenomenon. The current study aims to explain the mechanisms involved in multidrug resistance of childhood ALL, and introduces ATP-binding cassette...

Gout is a chronic arthritic disease associated with high levels of urate in blood. Recent advances in research have permitted the identification of several new and common genetic factors underlying the disease. Among them, a polymorphism in the ABC transporter gene ATP-binding cassette transporter isoform G2 has been highlighted. ATP-binding cassette transporter isoform G2 was found to be invol...