Two identical single-ascending-dose studies evaluated the safety and pharmacokinetics (PK) of AVI-6002 and AVI-6003, two experimental combinations of phosphorodiamidate morpholino oligomers with positive charges (PMOplus) that target viral mRNA encoding Ebola virus and Marburg virus proteins, respectively. Both AVI-6002 and AVI-6003 were found to suppress disease in virus-infected nonhuman prim...

There are no currently approved treatments for filovirus infections. In this study we report the discovery process which led to the development of antisense Phosphorodiamidate Morpholino Oligomers (PMOs) AVI-6002 (composed of AVI-7357 and AVI-7539) and AVI-6003 (composed of AVI-7287 and AVI-7288) targeting Ebola virus and Marburg virus respectively. The discovery process involved identificatio...

Background. Increasing rates of multidrug-resistant (MDR) Enterobacteriaceae (ENT) challenges infection control and antimicrobial stewardship practices. We evaluated the activity of ceftazidime-avibactam (CAZ-AVI), a cephalosporin combined with a serine-β-lactamase (BL) inhibitor displaying activity against ENT, including those producing contemporary BLs. Methods. 20,709 ENT isolates collected ...

BACKGROUND The arterial velocity pulse index (AVI) is explored as a novel marker of atherosclerosis using pulse wave analysis in clinical settings. Recent clinical studies have reported that the level of high-sensitivity troponin T (hs-cTnT) is an important biomarker in hypertensive patients. The aim of this study was to clarify the impact of AVI on hs-cTnT in these patients. METHODS This stu...

Arterial velocity pulse index (AVI) and arterial pressure-volume index (API), new indicators of arterial stiffness, are risk factors for the development of cardiovascular disease. Regular aerobic exercise decreases arterial stiffness. In fact, pulse wave velocity (PWV), index of arterial stiffness, is lower in endurance-trained than in untrained young adults. However, the effect of regular aero...

Automatic Vehicle Identification (AVI) is a mature technology having high reliability for vehicle detection. San Antonio TransGuide recently installed a number of AVI readers alongside inductive loop detectors placed on the same freeway sections, allowing side-by-side performance comparison. The principal objective of this study is to perform a systematic comparative evaluation of the performan...

In broadcast service operators would like the viewing of such a sufficiently corrupted video on the screen of the unauthorized viewer to allure potential customers without sacrificing the level of robustness provided by digital encryption techniques.A technique for embedding data in scrambled AVI video is described. The embedding technique is applied to the video sequence jointly with the video...

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). Disk diffusion and agar-based antimicrobial susceptibility testing were initially performed to determine the in...