نتایج جستجو برای: Aamyotrophic lateral sclerosis

تعداد نتایج: 178071  

Journal: :iranian journal of basic medical sciences 0
afagh alavi school of biology, college of science, university of tehran, tehran, iran marzieh khani school of biology, college of science, university of tehran, tehran, iran shahriar nafissi department of neurology, tehran university of medical sciences, tehran, iran hosein shamshiri department of neurology, tehran university of medical sciences, tehran, iran elahe elahi department of biotechnology, college of science, university of tehran, tehran, iran

objective(s): amyotrophic lateral sclerosis (als), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in european populations. approximately 10% of als cases are familial (fals) and the other patients are considered as sporadic als (sals). among many als causing genes that have been identified, mutations in sod1 and c9orf72 are the most common genetic causes...

Objective(s): Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been identified, mutations in SOD1 and C9orf72 are the most common genetic causes...

Journal: :medical journal of islamic republic of iran 0
mahmoud reza azarpazhooh department of neurology mashhad university of medical sciences, mashhadiran. address: no.380, sajad blvd, mashhad, iran.,سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) mohammad etemadi mashhad university of medical sciences.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) ebrahim poorakbar mashhad university of medical sciences.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) ali shoeibi mashhad university of medical sciences.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)

abstract   background: amyotrophic lateral sclerosis (als) is a progressive neurological disorder with high mortality and morbidity. some risk factors have been implicated for als such as exposure to high magnetic fields, and trace elements like selenium, cadmium and lead. afew studies have been carried out throughout the world to evaluate the prevalence of als among veterans. this study was ai...

Journal: :molecular and biochemical diagnosis (journal) 2014
parisa ghiasi saman hosseinkhani shahriar nafissi khosro khajeh

background: despite the genetic heterogeneity reported in familial als (fals), sod1 gene mutations are the most frequent cause of fals, accounting for around 20% of familial cases (als1) and isolated sporadic cases. mutant forms of sod1 exhibit toxicity that promotes the death of motor neurons. it is well documented that fals produces protein aggregates in the motor neurons of fals patients, wh...

Journal: :iranian journal of neurology 0
seyed-ali javad mousavi department of internal medicine, school of medicine, iran university of medical sciences, tehran, iran. babak zamani department of neurology, school of medicine, iran university of medical sciences, tehran, iran. shahab shahabi shahmiri department of scientific research center, school of medicine, iran university of medical sciences, tehran, iran. mohammad rohani department of neurology, school of medicine, iran university of medical sciences, tehran, iran. gholam ali shahidi department of neurology, school of medicine, iran university of medical sciences, tehran, iran. elyas mostafapour department of scientific research center, school of medicine, iran university of medical sciences, tehran, iran.

background: the rapidity of progression of amyotrophic lateral sclerosis (als) to death or respiratory failure impacts patients, clinicians, and clinical investigators. the aim of this study is to evaluate of the pulmonary function tests (pfts) in patients with als and the association between these pfts and survival methods: a total of 36 als patients who pfts, including vital capacity (vc), ma...

Journal: :acta medica iranica 0
a. tarazi s. nafissi a. a. amirzargar p. ayatollahi a. soltanzadeh

amyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. for many years, viruses have been suspected as causative agents. there are conflicting reports about the possible role of viruses such as human herpes virus 8 (hhv8) and retroviruses in the pathogenesis of the sporadic amyotrophic lateral sclerosis. we conducted a prospective case-control study to ...

2013
Yui Nakayama Satoru Morimoto Misao Yoneda Shigeki Kuzuhara Yasumasa Kokubo

Objective. Amyotrophic lateral sclerosis/parkinsonism-dementia complex is classified as one of the tauopathies. Methods. The total tau, phosphorylated tau, and amyloid β42 levels were assayed in cerebrospinal fluid from patients with Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex (n = 12), Alzheimer's disease (n = 9), Parkinson's disease (n = 9), amyotrophic lateral sclerosis (...

2010
Steve Vucic Benjamin C. Cheah Con Yiannikas Angela Vincent Matthew C. Kiernan

Acquired neuromyotonia encompasses a group of inflammatory disorders characterized by symptoms reflecting peripheral nerve hyperexcitability, which may be clinically confused in the early stages with amyotrophic lateral sclerosis. Despite a clear peripheral nerve focus, it remains unclear whether the ectopic activity in acquired neuromyotonia receives a central contribution. To clarify whether ...

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