Although uncommonly diagnosed, clear cell acanthoma represents an original source of speculative interest for dermatologists. Due to its clinical variability, it is often only recognized accidentally after histology. Dermoscopy has improved the reliability of clinical diagnosis of typical clear cell acanthoma thanks to the vascular pinpoint pattern and desquamative, peripheral collarette. Gener...

This article describes 31 examples of acantholytic acanthoma, a newly recognized, solitary, benign cutaneous tumor. Acantholytic acanthoma was typically an asymptomatic, keratotic papule or nodule. Patients ranged in age from 32 to 87 years (median 60 years); the ratio of men to women was 2:1; the most frequent clinical diagnosis was keratosis; and half of the growths were on the trunk of the b...

The coiled and dotted vessels in a serpiginous arrangement or "string of pearls" is considered a classical vascular pattern associated with clear cell acanthoma. We present three cases of epidermal tumors different from clear cell acanthoma that have the same "string of pearls" vascular pattern. Even though most authors keep considering the "string of pearls" vascular pattern an almost pathogno...

Clear cell acanthoma is a rare, epidermal tumor not common in the area of the nipples; indeed, the literature describes only 8 cases, all showing unilateral presentation. We here report the first case of bilateral clear cell acanthoma with good response to topical corticosteroids. CASE REPORT A sixteen-year old girl presented with 2 excrescent, fleshy, and exudative tumor masses in both nippl...

Brownstein described a previously unrecognized benign acanthoma, the "Acantholytic acanthoma" in 1988. We report a rare case of acantholytic acanthoma on the right labia minor of vulva in a 34-year-old woman. Due to the rarity of this lesion in the female genitalia, it may be confused with other lesions more commonly affecting this region. Correct diagnosis of acantholytic acanthoma may result ...

Epidermolytic acanthoma (EA) is a rare benign lesion described by Shapiro and Baraf in 1970. It typically presents clinically as a solitary, asymptomatic verrucous papule. Histologically, there is an epidermal proliferation (acanthoma) with epidermolytic hyperkeratosis, without the concomitant presence of signs suggestive of other cutaneous tumors. The presence of multiple EAs in the genital an...

Epidermolytic acanthoma is a rare benign tumour, which may occur in both isolated and disseminated forms. Only seven cases of disseminated epidermolytic acanthoma (DEA) have been described. This entity should be distinguished from other hereditary or acquired conditions which involve epidermolytic hyperkeratosis and other benign acanthomas. On the basis of the clinical history and the histologi...

THE main interest of kerato-acanthoma (molluscum sebaceum) is its resemblance to squamous-cell carcinoma of the skin: it is, however, benign and even self-healing, and it seems very likely that an appreciable number of lesions diagnosed as malignant in the past, and followed-up as such, were in fact examples of this condition, so that a mistaken diagnosis may result in gross over-treatment and ...

Clear cell acanthoma or Degos' acanthoma is a distinct disease concerning its clinical, histopathological, and immunohistochemical features. Its pathologic nature - whether neoplastic or reactive - is still under dispute among researchers. The disease shows a chronic course and often presents with a single papulonodular lesion on the lower limbs of adults. However, cases with multiple lesions, ...