نتایج جستجو برای: Acridone

تعداد نتایج: 167  

Journal: :Chemical & pharmaceutical bulletin 2000
T S Wu C M Chen

Eight new acridone alkaloids, buxifoliadines-A--H together with nine known acridone compounds, were isolated and characterized from the root bark of Severinia buxifolia which was collected in Hainan province, China. Their structures were determined by spectroscopic methods. The relationship between acridone alkaloids with collecting area is discussed. The 13C-NMR spectra of the prenyl substitue...

2011
Ramesh Kumar Meena Kumari

ABSTRACT A lot of work had been carried out on the acridone nucleus due to its variety of pharmacological activities. These pharmacological activities include anticancer, antimicrobial, antiviral, antimalarial and anti-inflammatory activities. Acridone and its derivatives can be synthesized by a number of methods such as Ullmann condensation, by benzyne mechanism, by radical reaction of quinine...

2013
Vyry NA Wouatsa Laxminarain Misra Shiv Kumar Om Prakash Feroz Khan Francois Tchoumbougnang R Kumar Venkatesh

BACKGROUND Zanthoxylum zanthoxyloides and Z. leprieurii fruits are commonly used in traditional system of medicine for diarrhea, pain, wound healing, etc. in Cameroon, Africa. Z. leprieurii fruits have been chemically studied for its bioactive compounds whereas the investigation on Z. zanthoxyloides fruits is lacking. RESULTS After a detailed chemical analysis of the fruits of Z. leprieurii a...

Journal: :Molecules 2011
Maizatul Akmal Yahayu Mawardi Rahmani Najihah Mohd Hashim Muhammad Aizat Mohd Amin Gwendoline Cheng Lian Ee Mohd Aspollah Sukari Abdah Akim

Extraction and chromatographic separation of the extracts of dried stem barks of Glycosmis macrantha lead to isolation of two new acridone alkaloids, macranthanine and 7-hydroxynoracronycine, and a known acridone, atalaphyllidine. The structures of these alkaloids were determined by detailed spectral analysis and also by comparison with reported data.

2015
Kuntebomanahalli Thimmaiah Apoorva G. Ugarkar Elvis F. Martis Mushtaque S. Shaikh Evans C. Coutinho Mayur C. Yergeri

Drug–DNA Interaction Studies of Acridone-Based Derivatives Kuntebomanahalli Thimmaiah, Apoorva G. Ugarkar, Elvis F. Martis, Mushtaque S. Shaikh, Evans C. Coutinho & Mayur C. Yergeri To cite this article: Kuntebomanahalli Thimmaiah, Apoorva G. Ugarkar, Elvis F. Martis, Mushtaque S. Shaikh, Evans C. Coutinho & Mayur C. Yergeri (2015) Drug–DNA Interaction Studies of Acridone-Based Derivatives, Nuc...

2013
Yini Wang Dan Gao Zhe Chen Shangfu Li Chunmei Gao Deliang Cao Feng Liu Hongxia Liu Yuyang Jiang

A new acridone derivative, 2-aminoacetamido-10-(3, 5-dimethoxy)-benzyl-9(10H)-acridone hydrochloride (named 8a) synthesized in our lab shows potent antitumor activity, but the mechanism of action remains unclear. Herein, we report the use of an UPLC/Q-TOF MS metabolomic approach to study the effects of three compounds with structures optimized step-by-step, 9(10H)-acridone (A), 10-(3,5-dimethox...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
J L Reymond T Koch J Schröer E Tierney

A simple and highly sensitive catalysis assay is demonstrated based on analyzing reactions with acridonetagged compounds by thin-layer chromatography. As little as 1 pmol of product is readily visualized by its blue fluorescence under UV illumination and identified by its retention factor (Rf). Each assay requires only 10 microliters of solution. The method is reliable, inexpensive, versatile, ...

2011
Javed Intekhab Mohammad Aslam Hira Khalid

Three quinolinone alkaloids, two acridone alkaloids and a flavones glycoside were isolated from the aerial parts of Glycosmis mauritiana. These compounds were characterized as 7, 8-Dimethoxy-2,2,6-trimethyl-pyrano quinolin-5-one, 4-Methoxy 1-methyl quinolin-2-one, 6-Hydroxy N-methyl 2,3-furo-quinolin-4-one, 1-Hydroxy-10-methyl acridone, 1Hydroxy-2, 3-dimethoxy-10-methylacridin-9-one and Luteoli...

Journal: :Chemical & pharmaceutical bulletin 2009
Chaisak Chansriniyom Nijsiri Ruangrungsi Vimolmas Lipipun Takuya Kumamoto Tsutomu Ishikawa

Six acridone alkaloids including a new glycosparvarine (1), three limonoids, and four N-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives including two new species, (+)-S-deoxydihydroglyparvin (10) and (+)-S-deoxytetrahydroglyparvin (11), were isolated from the branches and the leaves of Glycosmis parva CRAIB collected in the east of Thailand. Antiviral acti...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 1994
A Baumert W Maier D Gröger R Deutzmann

Acridone synthase has been purified from cell suspension cultures of Ruta graveolens using a combination of gel filtration and ion exchange chromatography. The purified enzyme has an apparent molecular weight of 69 kDa on gel filtration and a subunit structure on SDS-PAGE of 40 kDa. The apparent Km-values are 10.64 microM and 32.8 microM for N-methylanthraniloyl-CoA and malonyl-CoA, respectivel...

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