s are drawn spanning the circle. Conservatively, we treated all monogenic loci (region 142) as a single locus by which connectivity was assessed. The strongest connections (P < 0.001) are colored in bright red. (d) GSEA of associations in the adipocytokine signaling pathway. Black bars represent the stage 1 meta-analysis P values of 63 autosomal genes in the adipocytokine signaling pathways (KE...

Obesity is related to various diseases, such as diabetes, hyperlipidemia, and hypertension. Adipocytokine, which is released from adipocyte cells, affects insulin resistance and blood lipid level disorders. Further, adipocytokine is related to chronic inflammation in obesity condition adipocyte cells. Paprika pigments (PPs) contain large amounts of capsanthin and capsorubin. These carotenoids a...

AIM Alanine aminotransferase (ALT) and γ-glutamyltransferase (GGT) are associated with insulin resistance and arteriosclerotic disease. Since adiposity raises liver enzyme levels and causes insulin resistance, adipocytokines are thought to underlie the relationship between liver enzymes and insulin resistance. To clarify this hypothesis, we conducted a cross-sectional epidemiological study in a...

We determine the relative contribution adipocytokines to insulin resistance (IR) in urban Western Indian population. The serum adipocytokine [leptin, adiponectin, resistin, tumor necrosis factor (TNF), and interleukin-6 (IL-6)] levels and their association with IR in different metabolic disorders state like obesity and type 2 diabetes mellitus (T2DM) was determined. A total of 215 subjects incl...

objective (s):rheumatoid arthritis (ra) is a chronic systemic inflammatory disorder, primarily targeting the synovium and articular cartilage that leads to joint damage. recent reports have suggested the role of adipocytokines in mediating joint damage; however it still is a matter of debate. the purpose of this study was to evaluate the association between serum values of adiopocytokines (lept...

Aims. Adipocytokines are implicated in the pathogenesis of type 2 diabetes and may represent identifiable precursors of metabolic disease within high-risk groups. We investigated adiponectin, leptin, and TNF- α and assessed the contribution of these molecules to insulin resistance in south Asians. Hypothesis. South Asians have adverse adipocytokine profiles which associate with an HOMA-derived ...

background: visfatin is an adipocytokine secreted by visceral adipose tissue. it has been shown that adipocytokines may contribute to the induction of carcinogens and progression of tumors. previously, we found a significant increase in the visfatin serum level in colorectal cancer patients. herein, we investigated if this cytokine increases in patients with colorectal adenoma as a precursor of...

The adipose tissue is an endocrine organ producing substances called adipocytokines that have different effects on lipid metabolism, metabolic syndrome, and cardiovascular risk. Visfatin was recently described as an adipocytokine with potentially important effects on glucose metabolism and atherosclerosis. Visfatin has been linked to several inflammatory conditions, beta cell function, and card...