Christopher E Lowe,
Justin J Rochford,
Stephens, 2010). At the same time attention has also shifted to many other aspects of adipocyte development, including efforts to identify, isolate and manipulate relevant precursor stem cells. Recent studies have revealed new intracellular pathways, processes and secreted factors that can influence the decision of these cells to become adipocytes. Understanding the intricacies of adipogenesis ...
Bone marrow adipogenesis is a postnatal event during bone and marrow development. In the adult bone, marrow adipocytes occupy the largest space of the marrow cavity, and serve as a source of energy, autocrine and paracrine factors. Marrow adipocyte share a common multipotential mesenchymal stem cell with other marrow stomal lineages, and functional overlap exists among them. In the marrow strom...
:Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion2011
Manuel Ros Pérez,
Insulin resistance precedes the development of type 2 diabetes mellitus and is also a common denominator in the so-called metabolic syndrome. Although the cause of insulin resistance has not been fully elucidated, it seems clear that lifestyle changes, including little physical exercise and constant access to food, particularly in developed and economically emergent countries, as well as geneti...
The current global diabetes epidemic is driven by obesity. However, many obese individuals do not develop insulin resistance or the metabolic complications. Inappropriate expansion of the subcutaneous adipose cells leads to hypertrophic obesity characterized by a dysregulated adipose tissue with insulin resistance and inflammation. Here, we discuss the limited expandability of the subcutaneous ...
:American journal of physiology. Cell physiology2016
Adipose tissue plays a critical role in metabolic diseases and the maintenance of energy homeostasis. RACK1 has been identified as an adaptor protein involved in multiple intracellular signal transduction pathways and diseases. However, whether it regulates adipogenesis remains unknown. Here, we reported that RACK1 is expressed in 3T3-L1 cells and murine white adipose tissue and that RACK1 knoc...
:The Journal of clinical investigation2007
Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, ...
Theodore R Lin,
Michael W Mulholland,
Ghrelin, a novel gastric hormone, regulates food intake and energy metabolism via central mechanisms. The peripheral effect of ghrelin on adiposity is poorly understood. We established a stable 3T3-L1 cell line expressing ghrelin to study the direct effect of ghrelin on adipogenesis. Cells overexpressing ghrelin demonstrate significantly attenuated differentiation of preadipocytes into adipocyt...
Scheduled feeding induces adipogenesis 3 I Verbaeys *, V Tolle , Q Swennen, P Zizzari , J Buyse, J Epelbaum, M Cokelaere a 4 a Interdisciplinary Research Center, Katholieke Universiteit Leuven, Campus Kortrijk, 5 Etienne Sabbelaan 53, B-8500, Kortrijk, Belgium. 6 b INSERM UMR 894 Centre de Psychiatrie et Neurosciences, 2 ter rue d’Alésia, 75014 Paris, 7 France. 8 c Université Paris Descartes, F...
:Proceedings of the National Academy of Sciences of the United States of America2013
Loyal A Goff,
Kinyui Alice Lo,
David R Kelley,
David G Hendrickson,
Harvey F Lodish,
John L Rinn,
The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not been explored. Here we profiled the transcript...