A direct and an efficient conversion of a wide range of primary, secondary even tertiary alcohols to the corresponding iodides have been achieved under ionic liquid conditions. The method involves preparation of ionic liquid-based iminium chloride intermediate from DMF-like ionic liquid then stirring it with alcohol in present of sodium iodide. The higher yields of alkyl iodides were obtained w...

A direct and an efficient conversion of a wide range of primary, secondary even tertiary alcohols to the corresponding iodides have been achieved under ionic liquid conditions. The method involves preparation of ionic liquid-based iminium chloride intermediate from DMF-like ionic liquid then stirring it with alcohol in present of sodium iodide. The higher yields of alkyl iodides were obtained w...

a direct and an efficient conversion of a wide range of primary, secondary even tertiary alcohols to the corresponding iodides have been achieved under ionic liquid conditions. the method involves preparation of ionic liquid-based iminium chloride intermediate from dmf-like ionic liquid then stirring it with alcohol in present of sodium iodide. the higher yields of alkyl iodides were obtained w...

Reactions of super-electron-donors (SEDs) derived from 4-dimethylaminopyridine and from N-methylbenzimidazole with α-methoxy-γ-alkoxyalkyl iodides lead to liberation of the γ-alkoxy groups as their alcohols. This is consistent with generation of alkyl radicals from the alkyl halide precursors, and trapping of these radicals by the radical-cation of the SED, followed by a heterolytic fragmentation.

The first examples of Cu-catalyzed γ-selective allylic alkenylation using organozinc reagents are reported. (E)-Alkenylzinc iodides were prepared by Fe-catalyzed reductive coupling of terminal arylalkynes with alkyl iodides. In the presence of a copper catalyst, these reagents reacted with allylic bromides derived from Morita-Baylis-Hillman alcohols to give 1,4-dienes in high yields. The reacti...

It was observed that a PhSiH2I-mediated protocol using PhSiH3 and cat. I2 caused the deiodination of 2-(iodomethyl)-2-phenyltetrahydrofuran. Stemming from the investigation of the mechanism, we found that the PhSiH3-I2 system selectively promotes diverse cascade transformations from cyclic ethers to acyclic alkyl iodides, and the PhSiH3-N-iodosuccinimide (NIS) system also promotes cascade trans...

Racemic 1-(β-hydroxypropyl)azoles were prepared by solvent-free direct regioselective ring opening of 1,2-propylene oxide with imidazole or 1,2,4-triazole. Lipase-catalyzed transesterification of alcohols with vinyl acetate resulted in kinetic enantiomers resolution. Separated (S)-enantiomers of (+)-1-(1H-imidazol-1-yl)propan-2-ol and (+)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol were quaternized wi...

The use of surface-bound alkyl and phenyl groups as synthetic vehicles in coupling reactions on oxygen-activated Au(111) is demonstrated by the formation of ethers via alkyl and phenyl iodides. Ethers are formed by successive additions of surface-bound alkyl groups to adsorbed atomic oxygen to form first the alkoxy and then the ether. The addition of the ethyl group to adsorbed oxygen on Au(111...

Abstract: Neurotoxic organotin reagents currently play a key role in radical chemistry. As a result, this is an important area for development of new clean replacement reactions. The pharmaceutical industry in particular has had to avoid use of radical methodology for the formation of carbon–carbon bonds for this reason. With the current dawn in green chemistry, a host of new clean radical meth...

An orthogonal set of Cu-catalysts for the selective mono-arylation of alkyl aryl diols using aryl iodides is presented. Picolinic acid ligated copper catalyst provided phenol O-arylation only, while alkyl aryl ethers are generated by ligand-free copper catalyst in the presence of 2 equivalents NaOt-Bu.