1. Plasma aluminium concentration and urinary aluminium excretion were monitored for 4.5 h in rats after the administration of 25 micrograms or 800 micrograms of aluminium as an intravenous bolus, either as aluminium chloride or as aluminium citrate (i.e. aluminium chloride together with sodium citrate). 2. Immediately after the bolus aluminium administration, the plasma aluminium concentration...

Investigation of aluminium uptake by human erythrocytes was the major aim of this study. Packed red blood cells were incubated in Earle's medium (pH 7.4) containing varying concentrations of aluminium (0-160 /lg/J) as AIK(SO.), and aluminium content of the cells were determined using flameless atomic absorption. There was significant increase in aluminium content of the cells. Addition of 5...

The effects of aluminium and aluminium-citrate on some serum parameters related to carbohydrate metabolism in male Wistar rats were investigated. Daily intraperitoneal administrations of 1 mg/kg body weight of aluminium or aluminiumcitrate (1: 1) for 50 days led to the elevation of serum insulin by 24 or 40 percent respectively, with the concomitant decrease in serum glucose concentrations ...

investigation of aluminium uptake by human erythrocytes was the major aim of this study. packed red blood cells were incubated in earle's medium (ph 7.4) containing varying concentrations of aluminium (0-160 /lg/j) as aik(so.), and aluminium content of the cells were determined using flameless atomic absorption. there was significant increase in aluminium content of the cells. addition of ...

1. Rat gut perfusion studies in vivo at pH 4, 6 or 8 using aluminium chloride or equimolar aluminium chloride and sodium citrate showed that elevated plasma aluminium concentrations were associated with aluminium solubility in the perfusion. Elevated plasma aluminium levels and soluble aluminium in the perfusate occurred with perfusion of equimolar aluminium chloride and sodium citrate at all t...

the effects of aluminium and aluminium-citrate on some serum parameters related to carbohydrate metabolism in male wistar rats were investigated. daily intraperitoneal administrations of 1 mg/kg body weight of aluminium or aluminiumcitrate (1: 1) for 50 days led to the elevation of serum insulin by 24 or 40 percent respectively, with the concomitant decrease in serum glucose concentrations by 1...

INTRODUCTION Aluminium is a known neurotoxin and occupational exposure to aluminium has been implicated in neurological disease including Alzheimer's disease. Here we present the first comprehensive and unequivocal data demonstrating significantly elevated brain aluminium content in an individual occupationally exposed to aluminium. CASE PRESENTATION A 66-year-old Caucasian man who died with ...

Urinary excretion of aluminium after a successful transplant can reverse pre-transplant aluminium intoxication. We have evaluated the time course of urinary aluminium excretion and its correlation with several parameters of renal function and mineral metabolism in 49 patients (33 men and 16 women) with a wide range of pre-transplant serum aluminium concentrations, performing sequential determin...

Horse spleen ferritin was found to bind aluminium poorly after equilibrium dialysis with buffered aluminium citrate solutions. Not more than 10 aluminium atoms/ferritin molecule were bound from a 25 microM-aluminium solution, pH 7.4, and the degree of binding was dependent on the method used to prepare the aluminium citrate solution. Up to 120 aluminium atoms/molecule were bound when ferritin i...