A novel indirect electrochemical protocol for the electroanalytical detection of phenols is presented for the first time. This methodology is demonstrated with the indirect determination of the target analytes phenol, 2-chlorophenol, 4-chlorophenol and 2,4-dichlorophenol through an electrochemically adapted optical protocol. This electrochemical adaptation allows the determination of the above ...

Few new 4-aminoantipyrine based mixed ligand complexes having imidazole as a potential drug candidate, were designed, synthesized and characterized by analytical and spectral methods. The electronic absorption and electron paramagnetic resonance parameters of Cu(II) complex revealed that the Cu(II) ion exhibits a distorted octahedral geometry with the carbonyl oxygen atom of the 4-aminoantipyri...

Many drugs which are alkylamines undergo dealkylation in the body. For example aminopyrine (2), ephedrine (3), codeine (4), meperidine (5, S), methylamphetamine (7), and mephobarbital (8, 9) are all demethylated in ti~o. The removal of ethyl groups has been demonstrated with quinacrine,’ and an unusual t,ype of dealkylation, the loss of a B-chloroethyl group, occurs in the biotransformation of ...

A new series of heterocycles incorporating antipyrine moiety were synthesized via reactions of 4-aminoantipyrine 1 with carbon disulphide then alkylation and /or chloroacetic acid to produce dithiocarbamate and rhodanine 3, 4 and 9. Multi-component reaction (MCR) of 4-aminoantipyrine with carbon disulfide and DMAD afforded rhodanine 7. The interaction of 9 with diazonium salt, DMF-DMA, nitrous ...

A novel indirect electrochemical protocol for the electroanalytical detection of phenols is presented for the first time. This methodology is demonstrated with the indirect determination of the target analytes phenol, 2-chlorophenol, 4-chlorophenol and 2,4-dichlorophenol through an electrochemically adapted optical protocol. This electrochemical adaptation allows the determination of the above ...

Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4'-aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4'-aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activi...

The present work deals with the synthesis and evaluation of biological activities of 4-aminoantipyrine derivatives derived from a three-component Betti reaction. The synthesis was initiated by the condensation of aromatic aldehyde, 4-aminoantipyrine, and 8-hydroxyquinoline in presence of fluorite as catalyst in a simple one-step protocol. The reactions were stirred at room temperature for 10-15...

Abstract Reverse phase dispersive liquid- liquid microextraction (RP- DLLME) coupled with spectrophotometry is introduced for the detection of total phenol in the muscle tissue of fishes, such as Sphyraena genie, Otolithes ruber, Rastrelliger kangurta, Lutjanus johnii and Barbus Subquin Cunciatus. Phenols in fish tissues were extracted by ultrasonic bath and derivatization with 4- aminoant...

A new heterocyclic Schiff base ligands and their complexes have been synthesized from 4-aminoantipyrine, thiophene-2-Carboxaldehyde and 2-amino benzoic acid. The ligands and its transition metal complexes of Cu (II), Co (II), Ni (II) and Zn (II) are characterized by UV, FTIR NMR and Mass studies. The antibacterial and antifungal activity of the ligands and the metal complexes were tested.

In this work, two analytical methodologies based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) were developed for quantification of emerging pollutants identified in sewage sludge after a previous wide-scope screening. The target list included 13 emerging contaminants (EC): thiabendazole, acesulfame, fenofibric acid, valsartan, irbesartan, salicylic acid, diclofenac, c...