trichomoniasis, a worldwide prevalent infection, is a perfect example of interplay between the infecting parasite and the host, on which the presentation of disease depends. to study the pathogenesis, animal model is required for establishment of infection. in this study, by using strains of trichomonas vaginalis isolated from vaginal swabs and/or urine samples and maintained in axenic form fro...

alzheimer's disease (ad) is the most common form of neurodegenerative disorders. memory loss in an alert person and impairment in the function of language, attention, perception, judgment or problem solving can occur in patients with ad. however, there are some medications in order to delay the debilitating aspects of the disease; but unfortunately, scientists could not found approaches to...

enhanced immune cell trafficking into the central nervous system (cns) and disruption of the blood brain barrier are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae). however, recent studies suggest that the coagulation and the contact-kinin system might also be involved in ms developme...

the most popular animal models of alzheimer’s disease (ad) are transgenic mice expressing human genes with known mutations which do not represent the most abundant sporadic form of the disease. an increasing number of genetic, vascular and psychosocial data strongly support that the octodon degus, a moderate-sized and diurnal precocial rodent, provides a naturalistic model for the study of the ...

introduction: helicobacter pylori (h. pylori) is a gastric pathogen of primates and causes active chronic gastritis as well as peptic ulcers. a wide range of studies is in effect to prevent or cure helicobacter infection and thus its associated disorders. in order to test various drug regimens as well as potential vaccines against h. pylori infection, a suitable animal model is required which s...

purpose: the purpose of this study is to model cryptosporidiosis in laboratory animals. the parasites were inoculated into animalsand thenmultiplied. the process of proliferation was compared to controlcryptosporidiosis in humans. materials and methods: twenty-five laboratory mice (4-7 days of age) and twenty-five laboratory rats (5 days of age) were assigned to the category i while the categor...

in critically ill infants and children, intravascular (iv) access is sometimes very difficult. in such cases intraosseous (io) infusion should be used as the method of choice. however, in practice, different problems are experienced with this procedure. to overcome the practical problems and to confirm the efficacy of io infusion in reversing hypovolemic shock, an animal model was used by emplo...

to understand the mechanism of multiple sclerosis (ms), an autoimmune demyelinating disease, the researchers developed an experimental animal model for ms, which is called eae (experimental allergic encephalomyelitis). there are several methods for inducing this animal model. in this research the active eae, which is developed by injecting bovine myelin antigens into genetically susceptible ani...

b ackground: animal models with various combination of host-parasite have long been employed to study malaria pathogenesis. here, we describe the combination of plasmodium berghei anka infec- tion in inbred icr mice as a model of cerebral malaria (cm). m ethods: infection in mice was initiated by intraperitoneal injection of 2 x 107  (0.2ml) parasitized red blood cells (prbcs). r esults: this m...

methanolic extract of solanum trilobatum linn. (mest) belonging to the family of solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. the extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...