background: in modern life, the incidence of traumatic injuries increases daily. in accidents which lead to trauma, massive bleeding is the main cause of death. nowadays, many different chemical and herbal agents are available for quick control of bleeding. objectives: in this study, we compare the effectiveness of two different types of chemical agents for control of bleeding in an animal mode...

brain injury is a complex event leading to tissue damage and functional deficits by primary and secondary mechanisms. since the application of tissue engineering approaches is a new topic in the treatment of brain injury, producing a proper experimental model to evaluate the effects of tissue engineering products on damaged brain tissue is required. in the present study, a simple and reproducib...

spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the ...

We summarize some of the most frequenthly used rodent animal models of temporal lobe epileps and the impact of chemoconvulsants on them. Temporal lobe epilepsy is the most common epilepsy in humans in which seizures spread to the neighboring cortiase and hippocampal neuron loss and other neuropathological take place. Temporal lobe epilepsy and the other form of epilepsy cannot acquired in chini...

multiple sclerosis (ms) is a complex disease resulting from the occurrence of intermingled episodes of neuro-inflammation and degeneration. the temporal and spatial patterns in which these events occur are not well understood as well as the molecular substrates underlying it. myelin loss and gain, as well as axonal damage are considered crucial events influencing the course of the disease but t...

conclusions rats fed with a 30% calorie-restricted diet in comparison with to ad libitum fed controls for 8 days had significantly more prominent regression of inflammation. results decline of both body weight and paw volume was significantly more prominent in the case than in the control rats within the study period (p < 0.001 and < 0.001, respectively). paw volume decrease was more prominent ...

background : we report experimental myocardial infarction by occluding coronary arteries in ovine models. methods: twelve ewes were included in the study. after the chest was opened by left lateral thoracotomy incision, the second diagonal branch of the left anterior descending coronary artery was ligated at a point approximately 40% distant from its base. prophylactic antiarrhythmics were admi...

asthma is a chronic inflammatory disease of the airway with extensive airway remodeling. the ethical issues associated with the studies in asthmatic patients, required development of animal model of asthma. animal models of asthma can provide valuable information on several features of asthma pathogenesis and treatment. although these models cannot carry out all clinical features, they are valu...

conclusions in conclusion, our observations indicated that pcdna3.1 (+)-hbv1.3c was superior to aav/hbv plasmid for establishment of persistent hbv infection by hi, in vivo, and this mouse model could be useful for studies of hepatitis virology and for the development of innovatory treatments for hbv infections. results in 60% of the mice injected with pcdna3.1 (+)-hbv1.3c, hbsag, hbeag, hbcag ...