Annona muricata, commonly known as soursop, contains annonacin, acetogenin, and polyphenol which are known to have chemopreventive effects on cancer. In this study, we tend to evaluate the apoptosis-inducing effect of soursop (Annona muricata) leaf extract on the colorectal cancer cell line COLO-205 through the activities of caspase-3 which is a marker of cell apoptosis. Cell cultures were incu...

The study investigated the underlying molecular mechanisms of ethanol extract of Annona muricata. L induced liver cancer cell apoptosis. The anti-proliferative effect of ethanol extract of Annona muricata. L was evaluated by MTT assay. Flow cytometry was used to detect the cell cycle and apoptosis. TUNEL assay was used to confirm cell apoptosis. DCFH-DA fluorescent probe can detect the level of...

This study was carried out to investigate the effect of Ethanol extract of the seeds of Annona muricata on some meiotic parameters in the pest grasshopper Zonocerus variegatus. Adult grasshoppers were treated with 28μl of the Ethanol extract of sun dry seeds of Annona muricata and absolute ethanol (control) for 48 hours and all the parameters (chiasma frequency, formation of rod and ring shaped...

BACKGROUND Cancer cells rapidly acquire resistance leading to treatment failures. In the present study, we have evaluated the cytotoxicity of 17 methanol extracts from 11 Cameroonian medicinal plants against the sensitive leukemia CCRF-CEM cells and the best ones were further tested on a panel of 8 other human cancer cell lines, including various MDR phenotypes as well as against the normal AML...

BACKGROUND Annona muricata Linn which comes from Annonaceae family possesses many therapeutic benefits as reported in previous studies and to no surprise, it has been used in many cultures to treat various ailments including headaches, insomnia, and rheumatism to even treating cancer. However, Annona muricata Linn obtained from different cultivation area does not necessarily offer the same ther...

Numerous bioactive compounds and phytochemicals have been reported to be present Annona muricata (Soursop). Some of these chemical compounds have been linked to the ethnomedicinal properties of the plant and its antioxidant properties. The aim of this study was to assess the proximate composition, phytochemical constituents and in vitro antioxidant properties of A. muricata using standard bioch...

Annona muricata has been reported to treat several ailments such as headaches, insomnia, cystitis, liver problems, diabetes, hypertension, inflammation, dysentery, among others. The present study investigated the effect of ethanol leaf-extract of Annona muricata on serum total protein and albumin concentrations in albino rats using spectrophotometric methods. Twenty albino rats were randomly as...

The aim of this work was to screen extracts from Annona muricata and Annona reticulata in vitro against Plasmodium falciparum. Crude ethanolic extracts, methylene chloride fractions, aqueous fractions, subfractions and isolated compounds (stigmasterol-3-O-β-d-glucopyranoside, lichexanthone, gallic acid and β-sitosterol-3-O-β-d-glucopyranoside) were tested for cytotoxicity on erythrocytes and Hu...

The aim of this study was to evaluate repeated measures over the years to estimate repeatability coefficient and the number of the optimum measure to select superior genotypes in Annona muricata L. The fruit production was evaluated over 16 years in 71 genotypes without an experimental design. The estimation of variance components and the prediction of the permanent phenotypic value were perfor...

Aditya V. Ashok*, Srinivas A., Ravitej K., Gopinadh V. A. Srinivas, department of pharmaceutical chemistry, Hindu college of pharmacy, Guntur Andhrapradesh, India, [email protected]. K. Ravitej, department of pharmaceutical chemistry, Hindu college of pharmacy, Guntur Andhrapradesh, India, [email protected] V. Gopinadh, department of pharmaceutical chemistry, Hindu college of pharmacy, ...