Novel, diverse pyrido [2,3-d] pyrimidine and pyrimido [4,5-d] pyrimidine analogs were synthesized by the reaction of 1,3-substituted-5-cyano uracil derivatives with appropriate nucleophile under mild conditions. Utilising 5-cyano uracil with various substitutions as a substrate leads to rapid synthesis of annulated uracils with diverse biological properties.

THE LOSS OF GENOMIC URACIL HOMEOSTASIS AND AID-DEPENDENTACCUMULATION OF DNA DAMAGE IN B CELL LYMPHOMASbySOPHIA SHALHOUTMay 2015Advisor: Dr. Ashok S. BhagwatMajor: Chemistry (Biochemistry)Degree: Doctor of PhilosophyActivation-induced deaminase (AID) is a sequence-selective DNA cytosinedeaminase that introduces uracils in immunoglobulin genes. This DNA mut...

The unicellular organism, Noctiluca, has been examined with the electron microscope. The nucleus is small compared to the very large size of the cell, but the nuclear border has an organization which indicates an active nucleocytoplasmic exchange. Whereas annuli are missing over most parts of the nuclear membrane proper, there are "annulated vesicles" in a layer inside the nuclear membrane. The...

In the present research, silica bonded n-propyl-1,3,5-triazine-2,4,6-triamine (SPTT) was synthesized by direct incorporation of chloropropyl groups through co-condensation of tetraethyl orthosilicate (TEOS) and 3-chloropropyl trimethoxysilane (CPTMS) and subsequent grafting the melamine onto the propyl groups via simple nucleophilic substitution reaction. The catalyst has been characterized by ...

Columnar liquid crystalline bis-N-annulated quaterrylenes have been prepared from readily available N-annulated perylenes by DDQ/Sc(OTf)(3) oxidative coupling and ring-fusion.

This study is the first detailed ecotoxicological study of the annulated sea snake, Hydrophis cyanocinctus. Concentrations of lead, cadmium, nickel and vanadium were evaluated in muscle, liver, kidney, skin and blood of the annulated sea snake (H. cyanocinctus) and in the whole bodies of its main prey species (Periophthalmus waltoni and Boleophthalmus dussumieri) in the Hara Protected Area, the...

Herein, we report an efficient method for synthesis of novel selenocyanates amino pyrazole, uracil, and isoxazole derivatives using in situ triselenium dicyanide from the combination malononitrile selenium dioxide DMSO medium. Using same but changing stoichiometry reagents sequence addition temperature, symmetrical selenoethers pyrazoles uracils were prepared good yields. Furthermore, utilized ...

A highly stereoselective one-pot procedure for the synthesis of five-membered annulated hydroxycoumarins has been developed. By merging primary amine catalysis with silver catalysis, a series of functionalized coumarin derivatives were obtained in good yields (up to 91%) and good to excellent enantioselectivities (up to 99% ee) via a Michael addition/hydroalkoxylation reaction. Depending on the...

Tetrathiafulvalenes (TTF)-annulated [28]hexaphyrin affords an electron rich flexible π-conjugated system whose limiting conformations can be controlled through choice of solvents. The conformation-dependent intramolecular charge transfer character, as well as electron reserve capability of the hexakis-TTF annulated hexaphyrin, was analyzed.

Ig gene conversion is most likely initiated by activation-induced cytidine deaminase-mediated cytosine deamination. If the resulting uracils need to be further processed by uracil DNA glycosylase (UNG), UNG inactivation should block gene conversion and induce transition mutations. In this study, we report that this is indeed the phenotype in the B cell line DT40. Ig gene conversion is almost co...