A new anthranilic acid hydroxylase which catalyzes the conversion of anthranilic acid to 2,3-dihydroxybenzoic acid, has been partially purified from crude extracts of the mycelial felts of Aspergillus niger, grown in the presence of anthranilic acid. Neither 3-hydroxyanthranilic acid nor salicylic acid is an intermediate in this conversion. The enzyme is stabilized by glutathione and requires s...

Nanostructured poly(anthranilic acid) was synthesized by oxidative polymerization using potassium persulfate as an oxidant and malonic acid (MA) as dopant. The synthesized polymer was characterized by various techniques. The structure of poly(anthranilic acid) was confirmed by FT-IR spectroscopy. The UV-Vis spectra of poly(anthranilic acid) shows π-π* and inter-ring charge transfer bands. The s...

A new anthranilic acid hydroxylase which catalyzes the conversion of anthranilic acid to 2,3-dihydroxybenzoic acid, has been partially purified from crude extracts of the mycelial felts of Aspergillus niger, grown in the presence of anthranilic acid. Neither 3-hydroxyanthranilic acid nor salicylic acid is an intermediate in this conversion. The enzyme is stabilized by glutathione and requires s...

Tolfenamic acid, an anti-inflammatory drug (NSAID), is metabolized in vivo to form several oxidative metabolites which are all conjugated with beta-D-glucuronic acid. In this study, the metabolites of tolfenamic acid were identified by 1H nuclear magnetic resonance (NMR) spectroscopy in urine samples obtained on days 7 to 10 from a human volunteer after oral administration of 200 mg of the drug...

PURPOSE Anthranilic acid is an important, the aromatic intermediate in the degradation of tryptophan in kynurenine pathway. This compound plays an important role in the regulation of immunological processes as well shows antibacterial activity. The aim of our study was to estimate the concentration of anthranilic acid in saliva of young patients with orthodontic apparatus. We also assessed corr...

Anthranilic acid is known to be formed from kynurenine in animals and microorganisms (3-6) and to be degraded by cell-free extracts of a Pseudomonas species adapted to L-tryptophan (7). Catechol has been postulated as an intermediate in the catabolism of anthranilic acid on the basis of experiments utilizing sequential enzyme induction (8). Several groups of investigators have recently succeede...

Anthranilic acid is known to be formed from kynurenine in animals and microorganisms (3-6) and to be degraded by cell-free extracts of a Pseudomonas species adapted to L-tryptophan (7). Catechol has been postulated as an intermediate in the catabolism of anthranilic acid on the basis of experiments utilizing sequential enzyme induction (8). Several groups of investigators have recently succeede...

Yanofsky (1) originally proposed N-(5’-phosphoribosyl)anthranilic acid as the first intermediate after anthranilic acid in tryptophan biosynthesis in microorganisms. Evidence was subsequently found which suggested that this compound is formed enzymatically from anthranilic acid and ribosylpyrophosphate 5-phosphate (2, 3). Although the dephosphorylated form of PRA,’ N-ribosylanthranilic acid, ha...

In Streptomyces sp. 3022a, anthranilate synthetase is composed of two non-identical subunits. The major subunit (molecular weight, 72,000) converts chorismic acid to anthranilic acid, using ammonia as the source of the amino group. The smaller subunit (molecular weight 28,000 to 29,000) confers on the enzyme the ability to use glutamine instead of ammonia as a substrate. In this study, reactivi...

Rydon (1) has found that 4and 5-methylanthranilic acids inhibit the growth of Eberthella typhi and that this inhibition is reversed by anthranilic acid, indole, and tryptophan. He concluded that the two methyl compounds interfere with the synthesis of tryptophan at the stage of anthranilic acid. Interruption in the conversion of anthranilic acid to indole in Escherichia coli, caused by chloromy...