background the evidence of rapid spread of multidrug resistant mycobacterium tuberculosis (mdr–tb) strains especially in high risk communities, persuade clinicians to find new drugs for this problem. β– lactams with few or no side effects has been reviewed as an alternative drugs for this issue. this study carried out to determine the effectiveness of amoxicillin–clavulanate in a group of irani...

tuberculosis is an infectious disease caused by mycobacterium tuberculosis and is the primary cause of mortality in the world. m. tuberculosis strains are important intracellular pathogens causing infection in oxygen-rich macrophages in the lungs. the emergence of aids, declined socioeconomic standards and a lessened emphasis on tb control programs have contributed to the disease resurgence. re...

Anti-TB drugs for children: Aetiotropic therapy is used the treatment of tuberculosis (TB) in children, as well adult patients. Anti-tuberculosis (anti-TB drugs) are divided into 3 lines, taking account drug sensitivity Mycobacterium (MBT). First-line anti-TBdrugs (basic) to treat TB caused by drug-susceptible MBT. Second- and third-line (reserve) recommended MBT-induced multidrug-resistant (MD...

Hepatotoxicity, a serious adverse drug reaction in tuberculosis (TB) patients receiving anti-TB drugs, is one of the most challenging clinical problems worldwide. Despite increasing awareness of clinicians and public, even now it remains an enormous problem and causes of hospitalization and life-threatening events. Considering the importance of anti-TB drug-induced hepatotoxicity (DIH) as a maj...

Tuberculosis (TB) can usually be treated with a course of four standard, or first-line, anti-TB drugs. If these are misused or mismanaged (that is, when drugs are taken in the wrong combination, are fewer than those prescribed, or are taken in insufficient doses or not at the proper time), multidrugresistant TB (MDR-TB) can develop. MDR-TB is a form of disease resistant to the most important an...

BACKGROUND Multidrug-resistant tuberculosis (MDR-TB) drugs which is resistant to the major first-line anti-TB drugs, Isoniazid and Rifampicin, has become a major global challenge in tuberculosis (TB) control programme. However, its burden at community level is not well known. Thus, the aim of study was to assess the prevalence of primary and secondary resistance to any first line anti-TB drugs ...

background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

BACKGROUND Tuberculosis (TB) is a major infectious disease globally. Adequate and proper use of anti-TB drugs is essential for TB control. This study aims to study China's production capacity and sales situation of anti-TB drugs, and to further discuss the potential for China to contribute to global TB control. METHODS The production data of anti-TB drugs in China from 2011 to 2013 and the sa...