conclusions probable mechanism of suppression of energy generation is suppression of the rise in glucose. results listeria monocytogenes was controlled using 2 mm of osthole. treatment of l. monocytogenes by 2 mm osthole had no effect on the atp level. objectives osthole has antibacterial properties, but its mechanisms of action is still unknown. materials and methods two millimoles of osthole ...

A preliminary study was made on the antibacterial mechanism of copper-bearing antibacterial stainless steels against E.coli through experiments of microbiology such as EDTA (ethylenediaminetetraacetic acid) complexing, DNA smearing and AFM (atomic force microscope) observation. It was measured that the antibacterial stainless steels showed excellent antibacterial functions with antibacterial ra...

Objective(s): Polymeric nanofiber has a huge potential for a various biomedical applications such as wound healing and orthopedic implant. Since most of the future applications of therapeutic nanofiber are interacting with human blood components, it is important to investigate hemocompatibility. Methods: In this study, nanofibers with antibacterial properties were synthesizedby elec...

Polypyrrole-chitosan nanocomposite (PPy-CTN) was synthesized by dispersion polymerization of PPy in presence of CTN. Preparation of spherical PPy nanoparticles that were successfully covered with a thin layer of chitosan was confirm by transmission electron microscopy (TEM) technique. Characterization techniques also revealed the presence of CNT in the polymer matrix and its presence was confir...

Essential oils present a fine antibacterial performance against a variety of bacteria. The main component of the cinnamon oil was eugenol (75.52%). In this study, the goal was to evaluate the antimicrobial activity and reveal bactericidal mechanism of cinnamon oil. Firstly, the minimum inhibitory concentration (MIC) and the minimum bactericide concentration (MBC) of cinnamon oil were tested. Th...

In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and...

Oxazolidinones are prominent among the new Gram-positive antimicrobial agents now becoming available. They were discovered by DuPont Pharmaceuticals in the late 1980s but linezolid, the first analogue suitable for development, was found only when the family was re-examined by Pharmacia in the 1990s. Oxazolidinones bind to the 50S subunit of the prokaryotic ribosome, preventing formation of the ...