نتایج جستجو برای: Antimalarial drug

تعداد نتایج: 593571  

Journal: :iranian journal of pharmaceutical research 0
mahdi mojarrab novel drug delivery research center, school of pharmacy, kermanshah university of medical sciences, kermanshah, i.r.iran. rozhin naderi 1)novel drug delivery research center, school of pharmacy, kermanshah university of medical sciences, kermanshah, i.r.iran. 2) student research committee, kermanshah university of medical science, kermanshah, i.r.iran fariba heshmati afshar 3department of traditional pharmacy, faculty of traditional medicine; and medicinal philosophy and history research center, tabriz university of medical sciences, tabriz, i.r. iran

the formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. in this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. fifteen extracts with different polarity from three iranian artemisia species, a. ciniformis, a. biennis an...

Journal: :iranian journal of medical sciences 0
arezoo rafiee parhizgar malaria and vector research group (mvrg), biotechnology research center (brc), pasteur institute of iran, tehran, iran; and department of medicinal chemistry, pharmaceutical sciences branch, islamic azad university, tehran, iran aazr tahghighi malaria and vector research group (mvrg), biotechnology research center (brc), pasteur institute of iran, tehran, iran

antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (cq) and amodiaquine (aq), have been used to prevent and treat malaria for many years. the importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. in recent years, with the spread of parasite resistance to cq and cross-resist...

Journal: :Journal of Clinical Investigation 2004

Journal: :Current opinion in chemical biology 2007
Michael H Gelb

The prevalence of resistance to known antimalarial drugs has resulted in the expansion of antimalarial drug discovery efforts. Academic and nonprofit institutions are partnering with the pharmaceutical industry to develop new antimalarial drugs. Several new antimalarial agents are undergoing clinical trials, mainly those resurrected from previous antimalarial drug discovery programs. Novel anti...

Journal: :iranian journal of blood and cancer 0
paul c chikezie comfort c monago augustine uwakwe

background: malaria remains the world’s most devastating human parasitic infection. our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (fansidartm, halfantm, quinine, coartemtm and chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (hb aa, hb as and hb ss). materials and methods: spectrophotometric metho...

The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis an...

2015
Shengyong Ng Robert E. Schwartz Sandra March Ani Galstian Nil Gural Jing Shan Mythili Prabhu Maria M. Mota Sangeeta N. Bhatia

Malaria eradication is a major goal in public health but is challenged by relapsing malaria species, expanding drug resistance, and the influence of host genetics on antimalarial drug efficacy. To overcome these hurdles, it is imperative to establish in vitro assays of liver-stage malaria for drug testing. Induced pluripotent stem cells (iPSC) potentially allow the assessment of donor-specific ...

The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis an...

Journal: :Nature Reviews Drug Discovery 2019

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