introduction : pemphigus comprises a group of diseases characterized by cutaneous and mucosal blistering. pemphigus vulgaris (pv) is the most common and important variant. recent reports have revealed the relatively high incidence of pv in iran. the onset or aggravation of many human diseases is attributed to oxidative stress and it has been suggested as one of the several factors responsible f...

numerous studies have been focused on natural anticarcinogenic agents. many antioxidants have been identified as anticarcinogens. antimutagens have also been proposed as cancer chemopreventive agents. the use of natural products as anticancer has a long history that began with traditional medicine. the aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...

background and objective: gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors. method: this research was performed in human and animal cell bank of iranian biological resource center, and cyt...

the etiopathogenesis of dementia in alzheimer's disease (ad) is still unclear. however, long-term oxidative stress is believed to be one of the major contributing factors in progression of neuronal degeneration and decline of cognitive function in ad. in order to assess the presence of oxidative stress in ad, we examined the enzymatic activities of the erythrocyte cu-zn superoxide dismutase (cu...

introduction: the principal dose-limiting factor in the use of cisplatin as an antineoplastic drug is its hepatic toxicity. this study was designed to investigate the protective role of taurine against cisplatin-induced hepatic injury. methods: male albino rats (180-220 g) were divided in to 4 groups (n=8) as follows: (1) saline-treated group (2): cisplatin-treated group (10 mg/kg ip) (3): grou...

The dietary supplements with claimed antioxidant activity constitute a substantial part of the dietary supplement market. In this study, we performed the LC-QTOF-MS analysis and investigated the activity profiles of popular antioxidant dietary supplements from different chemical groups in terms of quality control. The commonly used antioxidant tests and statistical analysis revealed that substa...

Preterm infants are vulnerable to the oxidative stress due to the production of large amounts of free radicals, antioxidant system insufficiency, and immature oligodendroglial cells. Reactive oxygen species (ROS) play a pivotal role in the development of periventricular leukomalacia. The three most common ROS are superoxide (O2(•-)), hydroxyl radical (OH(•)), and hydrogen peroxide (H2O2). Under...

Exposure to tobacco smoke impairs the antioxidant defense mechanisms. In female Wistar rats fed on regular rodent chow and supplemented with a flavonoids rutin, Trolox Equivalent Antioxidant Capacity (TEAC) was measured as an ABTS-radical cation reduction power in plasma, lungs, liver, brain and kidneys. Exposure to smoke reduced the TEAC values in the liver, brain and kidneys and enhanced anti...

Plants of Euphorbiaceae are used to cure various diseases in traditional systems of medicine. For present study, Homonoia riparia, Kirganelia reticulata, Phyllanthus fraternus and Pedilanthus tithymaloides were selected on the basis of their availability and antimicrobial activity. Plant phenolics and flavonoids are known to possess antioxidant activity. Hence, it was decided to evaluate the an...

In this study, the antioxidant activity of the Convolvulus arvensis Linn (CA) ethanol extract has been evaluated by different ways. The antioxidant activity of the extract assessed by 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical cation, the oxygen radical absorbance capacity (ORAC) and the ferric reducing antioxidant power (FRAP) was 1.62 mmol Trolox equivalents (TE)/g ...