BACKGROUND Rubbing moist skin results in higher frictional forces than rubbing very dry skin. As friction increases, the probability of activity-related blisters also increases. Therefore reducing moisture may reduce blister incidence during physical activity. OBJECTIVE We examined whether an antiperspirant can reduce foot blisters during hiking. METHODS In a double-blind study, cadets atte...

BACKGROUND Individuals with axillary hyperhidrosis have much higher than average sweat rates and are often prescribed anhydrous aluminum chloride (AlCl(3)) solutions. Topical application of these solutions can be irritating to the skin, resulting in poor compliance and lower than desired efficacy. OBJECTIVE Demonstrate the efficacy of an over the counter "clinical strength" soft-solid antiper...

The rumor that antiperspirant use causes breast cancer continues to circulate the Internet. Although unfounded, there have been no published epidemiologic studies to support or refute this claim. This population-based case- control study investigated a possible relationship between use of products applied for underarm perspiration and the risk for breast cancer in women aged 20-74 years. Case p...

introduction: size of axillary lymph nodes can be a predictor for breast abnormalities. the agents in the antiperspirants such as aluminum were observed in the breast biopsy of individual with abnormalities and antiperspirants usage. in this study, the relation between using antiperspirants and the size of axillary lymph nodes were evaluated in iranian women. methods: in this study, 120 women w...

Introduction: Size of axillary lymph nodes can be a predictor for breast abnormalities. The agents in the antiperspirants such as Aluminum were observed in the breast biopsy of individual with abnormalities and antiperspirants usage. In this study, the relation between using antiperspirants and the size of axillary lymph nodes were evaluated in Iranian women. Methods: In this study, 120 wo...

Use of underarm aluminium (Al)-based antiperspirant salts may be a contributory factor in breast cancer development. At the 10th Keele meeting, Al was reported to cause anchorage-independent growth and double strand DNA breaks in MCF10A immortalised non-transformed human breast epithelial cells. We now report that exposure of MCF10A cells to Al chloride or Al chlorohydrate also compromised DNA ...

BACKGROUND Eccrine sweat secretion is of central importance for control of body temperature. Although the incidence of sweat gland dysfunction might appear of minor importance, it can be a real concern for people with either hypohidrosis or hyperhidrosis. However, sweat gland function remains relatively poorly explored. OBJECTIVES To investigate the function of single human sweat glands. ME...

BACKGROUND Elevated concentrations of doxorubicin are found in eccrine sweat glands of the palms and soles. We therefore evaluated an antiperspirant as preventive treatment for palmar-plantar erythrodysesthesia (hand-foot syndrome) in patients with metastatic breast cancer treated with pegylated liposomal doxorubicin. PATIENTS AND METHODS An antiperspirant containing aluminum chlorohydrate or...