OBJECTIVE To compare the effectiveness of tepid sponging and antipyretic drug versus only antipyretic drug among febrile children. DESIGN Randomized controlled trial. SETTING Tertiary care hospital. PARTICIPANTS 150 children 6 mo - 12 yr age with axillary temperature 101F. INTERVENTION Tepid sponging and antipyretic drug (Paracetamol) (n=73) or only antipyretic drug (Paracetamol) (n=77)...

Although various forms of therapy have been used, since antiquity, to lower the temperature of febrile patients, it is still not known whether the benefits of antipyretic therapy outweigh its risks. Justifications for the use of antipyretic drugs, and the evidence pertaining to these rationales, are examined. Antipyretic therapy in sepsis, and adverse effects of antipyretic medications, are als...

BACKGROUND AND OBJECTIVE The effect of antipyretic therapy on mortality in patients with sepsis remains undetermined. The present study aimed to investigate the role of antipyretic therapy in ICU patients with sepsis by using a large clinical database. METHODS The multiparameter intelligent monitoring in intensive care II (MIMIC- II) database was employed for the study. Adult patients with se...

Anti-inflammatory and antipyretic activities of leaf extract of Clausena anisata were evaluated to ascertain the folkloric claim of its anti-inflammatory and antipyretic effects. The crude leaf extract (39–117mg/kg) of C. anisata was investigated for anti-inflammatory and antipyretic activities using various experimental models. The extract caused a significant (p<0.05–0.001) dose-dependent red...

The acetone extracts of Radix paeoniae (Paeonaceae) root (100 and 200 mg/kg orally) were tested in brewer's yeast-induced pyrexia in rats to assess their antipyretic activity. The pyrexia in rats was reduced significantly (P < 0.05) compared to that of control. These results indicate that the extracts possess antipyretic properties. The root extract showed significant reduction in normal body t...

Screening of different extracts and fractions from the plant Bidens pilosa Linn. var. (Asteraceae) has been conducted using the in-vitro comet assay for anticancer and the antipyretic action, which was done with in-vivo models. The extract from whole plant was extracted with n-hexane, chloroform and methanol extract (E1 - E3). The extracts were fractioned by column chromatography method and fra...

BACKGROUND Antipyretic medications are widely used in critically ill patients with infection despite evidence supporting a protective, adaptive role of fever. OBJECTIVE To assess the mortality risk of antipyretic medications among critically ill patients with infection. METHODS A systematic search of MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and PubMed was undertak...

Although physical methods of cooling are the treatment of choice for hyperthermia, their value in the treatment of fever remains uncertain. Methods involving convection and evaporation are more effective than those involving conduction for the treatment of hyperthermia. These same methods, combined with antipyretic medication, are preferable to immersion as treatment for fever in young children...

Antipyretic effects of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of Peperomia pellucida (Linn.) HBK (Fam. Piperaceae) were investigated. Intraperitoneal administration of boiled milk at a dose of 0.5 ml/kg body weight in albino rabbit leads to pyrexia. Intraperitoneal (i.p.) administration of petroleum ether and ethyl acetate soluble fractions of ethan...