polyclonal anti-thymocyte globulin (atg) is used as an immunosuppressive agent in the treatment of aplastic anemia (aa). serum sickness is a recognized side effect of atg. we observed abnormal skin manifestation in patient with aplastic anemia who had been treated with atg. we conclude that abnormal immune function caused by aplastic anemia and atg and corticosteroids may aggravate the signs of...

there is a well-recognized relationship between aplastic anemia and viral hepatitis. clinically apparent hepatitis precedes aplastic anemia by a period of weeks to months. hepatitis is an infrequent cause of aplastic anemia and is usually severe and fatal if untreated. the clinical features and, particularly the response to immunosuppressive therapy strongly suggest that immune mechanisms media...

Aplastic anemia is an immunosuppressed illness that difficult to treat. Planning for future renal transplantation in such individuals makes the situation more challenging since we must continue immunosuppression necessary a stable allograft while also ensuring aplastic remission.

anemia is the most common hematologic disorder in patients with ulcerative colitis (uc). in some cases, normochromic anemia results from the presence of chronic disease; however blood loss or malabsorption may lead to an iron deficiency anemia with hypochromic appearance. other rare hematologic manifestations associated with uc include myelodysplastic syndromes and leukemia. several investigato...

Patients with reduced ability to metabolize environmental carcinogens or toxins may be at risk of developing aplastic anemia. Glutathione S-transferase (GST) has been implicated in detoxifying mutagenic electrophilic compounds. This study asked whether the homozygous gene deletions of GSTM1 and GSTT1 affect the likelihood of developing aplastic anemia. The incidence of GSTM1 and GSTT1 gene dele...

UNLABELLED Background Associations between aplastic anemia and numerous drugs, pesticides and chemicals have been reported. However, at least 50% of the etiology of aplastic anemia remains unexplained. DESIGN AND METHODS This was a case-control, multicenter, multinational study, designed to identify risk factors for agranulocytosis and aplastic anemia. The cases were patients with diagnosis o...

Background: When it comes to the treatment of aplastic anemia fever, Guidelines for Aplastic Anemia regards Anti-thymocyte globulin (ATG) combined with eltrombopag as standard immunosuppressive plan, and ATG is main mode treat severe anemia. A large number prospective studies clinical trials have confirmed application value in Although brings satisfactory results, safety long-term use still unc...

Diffuse eosinophilic fasciitis (Shulman disease) is a rare sclerodermiform syndrome that, in most cases, resolves spontaneously or after corticosteroid therapy. It has been associated with hematologic disorders, such as aplastic anemia. The clinical features and long-term outcomes of patients with eosinophilic fasciitis and associated aplastic anemia have been poorly described. We report the ca...

The mechanism which produces marrow failure in idiopathic aplastic anemia is still unknown. Recent investigations have suggested the crucial role of NK cells in the regulation of normal hematopoiesis. In this study, the cytotoxic activity of mononuclear cells from human bone marrow and peripheral blood was examined against three NK-sensitive target cell lines in 15 patients with aplastic anemia...

Chloramphenicol is a widely used antibiotic. It is also well known to cause some potentially lethal complications such as aplastic anemia, acute leukemia and paroxysmal nocturnal haemoglobinuria Al though development of aplastic anemia is relatively more frequent, evidence in favour of acute leukemia caused by chloramphenicol is mostly circumstantial. Very rarely, aplastic anemia caused by chlo...