objective: curcumin, is the active component in turmeric (curcuma long). this agent induces apoptosis via inhibiting various signaling pathways. however, its poor aqueous solubility prevents its widespread application. in this study, dendrosomes with water-solubility, nano-sized dimensions and nontoxic properties, was used for curcumin delivery to cells. materials & methods: in the present...

background and objective: the management of apoptotic cell death has been considered as a putative therapeutic strategy for cancer treatment. in the present study we investigated the putative pro-apoptotic effect of allicin, the main garlic organosulfur component with repeatedly claimed chemopreventive potency, on the human adenocarcinoma cell line ht29 as an apoptosis resistant cell line, in v...

introduction: apoptosis is a major consequence of ionizing radiation in proliferative tissues and quantification of the apoptotic cells could be helpful for noninvasive assessment and estimation of the radiation absorbed dose. annexin v conjugated with super paramagnetic iron oxide nanoparticles (anx-spio) is a biological probe for detection of apoptotic cells using magnetic resonance imaging. ...

cladribine acts as an antineoplastic, immunosuppressive and anti-inflammatory agent. the aim of this study was to examine the possible impact of this drug on the epidermis of wistar rats. the control group received standard feed and water. the experimental group i was treated with cladribine in a schema corresponding to the treatment of multiple sclerosis in humans. the material for microscopic...

the study was conducted to evaluate the effect of thermal stress on expression profile of genes related to apoptosis in peripartum sahiwal cows. for this, twelve pregnant dry sahiwal cows were selected from livestock research centre at national dairy research institute, karnal. the cows were divided into two groups consisting of six sahiwal cows each. cows of group i calved during thermoneutral...

fragrant species of the genus salvia have been attributed many medicinal properties, which include anticancer activity. in the present study, cytotoxic properties of total methanol extract of salvia chloroleuca rech. f. & aellen and its fractions were investigated on mcf-7, a breast carcinoma cell line. malignant and non-malignant cells were cultured in rpmi medium and incubated with different ...

econazole nitrate (en), a synthetic compound, is now in use as a routine antifungal drug. en was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. in this research, the apoptosis-inducing effect of en on mcf-7 cells was investigated. the results showed that en inhibited the proliferation of mcf-7 cells in a time- and dose-dependent manner by mtt method ...

apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. it is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal dna fragmentation. although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

background: gastric cancer is the fourth common malignancy and the second prevalent cause of cancer death in the world. genetic and environmental factors play an important role in the development of this cancer. nutritional and epidemiological studies have indicated that folate status modulates the risk of developing cancer and apoptosis has been reported to play a decisive role in precancerous...

nitric oxide (no) derived from activated macrophages has been shown to be crucial for the host's leishmanicidal activities. excess no, however, can in¬duce apoptosis in some cell types, including macrophages. in the present inves¬tigation, we studied the role of no in inducing apoptosis of balb/c mice mac¬rophages infected with leishmania major in vitro. the peritoneal macrophages were harveste...