Background:  Diplopia, or double vision, is a common ophthalmologic complaint with many underlying causes, ocular and neurological. Aripiprazole has been reported to have fewer adverse effects and better efficacy than other atypical antipsychotics. Although ocular side effects of aripiprazole are not remarkable, two cases of diplopia associated with aripiprazole have been reported in the litera...

Objective(s):There are supportive evidences about the possible role of latent Toxoplasma. gondii infections on the behavior and neurologic functions, such as increased dopamine levels in the brain. The aim of this study was to examine anti-toxoplasma activity of aripiprazole that is an atypical anti-psychotic drug in mice. Materials and Methods: Mice were randomly divided into four groups, inc...

  Objective(s): The aim of this work was to investigate the effect of the natural and the chemically modified form of cyclodextrins namely; β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) respectively on the solubility and dissolution rate of aripiprazole; an antipsychotic medication showing poor aqueous solubility.   Materials and Methods: Phase solubility of ar...

background: second-generation antipsychotics, approved for the treatment of mania, are associated with adverse effects such as weight gain and metabolic disorders. aripiprazole, a recently introduced second-generation antipsychotic, are thought to account for its low propensity for weight gain, metabolic disturbances and sedation. the purpose of this study was to investigate the effect of rispe...

objective(s):there are supportive evidences about the possible role of latent toxoplasma. gondii infections on the behavior and neurologic functions, such as increased dopamine levels in the brain. the aim of this study was to examine anti-toxoplasma activity of aripiprazole that is an atypical anti-psychotic drug in mice. materials and methods: mice were randomly divided into four groups, incl...

Aripiprazole is a D2 and D3 receptor partial agonist that is unlike other second generation antipsychotics. The effectiveness of aripiprazole with regard to neurocognitive function and its adverse effects is unclear. The present study evaluates the comparative efficacy, effects on neurocognitive function, and adverse effects of aripiprazole and risperidone in the treatment of hospitalized patie...

BACKGROUND Aripiprazole lauroxil is an extended-release prodrug of aripiprazole for intramuscular injection, approved for schizophrenia treatment. We developed a population pharmacokinetic (PopPK) model to characterize aripiprazole lauroxil PK and evaluate dosing scenarios likely to be encountered in clinical practice. METHODS Data from 616 patients with schizophrenia, collected from 5 clinic...

BACKGROUND Well-tolerated and effective therapies for bipolar mania are required. AIMS To evaluate the efficacy and tolerability of aripiprazole as acute and maintenance of effect therapy in patients with bipolar I disorder experiencing manic or mixed episodes. METHOD Patients were randomised to double-blind aripiprazole (15 or 30 mg/day; n=167), placebo (n=153) or haloperidol (5-15 mg/day,...

OBJECTIVE To assess the effects of maintenance therapy with aripiprazole once-monthly 400mg on personal and social functioning. METHODS Data were analyzed from 2 randomized, double-blind trials of patients with schizophrenia requiring chronic antipsychotic treatment. One study was a 52-week trial of aripiprazole once-monthly 400mg versus placebo; the other was a 38-week trial of aripiprazole ...

Objective: Four different methods were used for stability indicating determination of aripiprazole in presence of its oxidation product in pure and its dosage form. Methods: The described methods are namely, second derivative spectrophotometry, first-derivative of ratio spectra; bivariate and thin layer chromatography. Results: The derivative spectrophotometric method was based on measuring the...