A series of arylidine barbituric acid derivatives was synthesized by Knoevenagel condensation reaction of aromatic aldehydes with barbituric acid or thiobarbituric acid using dodecylbenzenesulfonic acid as a Brønsted acid-surfactant catalyst in aqueous media. Regardless of the nature of the substitution (electron-donating and -withdrawing), all the reactions were completed within 15-65 min in w...

A series of arylidine barbituric acid derivatives was synthesized by Knoevenagel condensation reaction of aromatic aldehydes with barbituric acid or thiobarbituric acid using dodecylbenzenesulfonic acid as a Brønsted acid-surfactant catalyst in aqueous media. Regardless of the nature of the substitution (electron-donating and -withdrawing), all the reactions were completed within 15-65 min in w...

The parent barbituric acid and 2-thiobarbituric acid are convenient starting compounds for the preparation of different fused heterocycles and 5-substituted derivatives which are pharmacologically one of the most important classes of barbituric acid based compounds. The fused compounds of barbituric and thiobarbituric acid 7-(4-aminophenyl)-5-aryl5H-pyrano [2, 3-d] pyrimidinone, 5a-f have been ...

Aim: Dimedone , gamma pyrone and barbituric acid and their derivatives have also been found to be very important from their application point of view. Thus our aim was to prepare more derivatives from them. Method : Dimedone , gamma pyrone and barbituric acid have been treated with dimethyl sulphoxide and acetic anhydride reagent under varying temperature conditions in order to get more compoun...

or luminal (di-phenyl-barbiturie acid), (7) sodium luminal, (8) phanodorn (cyclo-hexenyl-ethyl-barbituric acid), (9) evipan (N. methyl-cyclo-hexenyl-methylbarbituric acid), (10) sodium evipan, (11) pentobarbitone (ethyl-methyl-butyl-barbituric acid) and (12) its sodium salt, nembutal, (13) ipral (calcium ethyl iso-propyl-barbituric acid), (14) allonal (a combination of allyl-iso-propyl-barbitur...

A copper catalyzed one-pot, three component reaction between barbituric acid, aldehydes and terminal alkynes has been developed for the construction of pyrano[2,3-d]pyrimidines via a tandem conjugative alkynylation/6-endo cyclization pattern. Screening of barbituric acid derived organic acceptors in conjugative alkynylation reaction and the synthetic applicability of conjugative addition produc...

BACKGROUND Thiazolidinone, has been employed in the preparation of different important drugs required for treatment of inflammations, bacterial infections, and hypertension. Mannich bases have been shown to exhibit diverse biological activities, such as antibacterial, and antifungal activities. Spiroheterocycles including thiazolidine moiety have antimicrobial activity. RESULTS In this study,...

efficient knoevenagel condensation of barbituric acid with different aromatic aldehydes on basic alumina was performed in a conventional microwave over in the absence of solvent.

Earlier studies (1, 2) from this laboratory indicated that in the dog the alkyl side chains of pentobarbital and Amytal do not undergo w oxidation but are subject to oxidation at the y-carbon atom of the amyl chains. Dogs excrete pentobarbital as two optically active diastereoisomers of ethyl(3hydroxy-1-methylbutyl)barbituric acid and Amytal as ethyl(3-hydroxyisoamyl)barbituric acid. In order t...