background: toxoplasma specific igm antibodies; the common serologic marker in diagnosis of acute toxoplasmosis has its own limitations. confirmatory testing with other markers, introduced as a complementary tool in distinguish acute and chronic infections is unusual in iran. in the present study, we investigated the cor-relation between the results of igm elisa, iga elisa, and igg avidity test...

Background: Toxoplasmosis is well known as an important infection in pregnant women. Although many serologic methods are available, diagnosis of early Toxoplasmosis may be extremely difficult. Objective: To detect the Toxoplasma IgG antibodies developed at the early stage of infection in pregnant women. Methods: 225 pregnant women, who were in the 2nd to 4th month of their pregnancy, enrolled i...

objective: toxoplasma gondii infection, an intracellular parasite, is often asymptomatic or is caused by different clinical diseases without being detected. evaluation of igg, iga, and igm in order to diagnose the pending toxoplasmosis may confront some problems. several researches has showned that toxo igg avidity can be useful in the recent active toxoplasmosis. in current study, modification...

background: toxoplasmosis is well known as an important infection in pregnant women. although many serologic methods are available, diagnosis of early toxoplasmosis may be extremely difficult. objective: to detect the toxoplasma igg antibodies developed at the early stage of infection in pregnant women. methods: 225 pregnant women, who were in the 2nd to 4th month of their pregnancy, enrolled i...

since the incidence of symptomatic congenital cytomegalovirus infection is low (~0.05%) and risk factors are not well defined, it is difficult to develop strategies for prevention. the aim of this study was to recognise the utility of specific immunoglobulin g avidity analysis for distinguishing primary infection from past/recurrent infection. sera from 50 women with cytomegalovirus specific im...

Avidity of immunoglobulin G (IgG) is defined as its binding strength to target antigen. As a consequence affinity maturation the IgG response, avidity maturing well. Therefore, acute infections are characterized by low-avidity IgG, whereas past usually associated with high-avidity IgG. also observed optimal vaccination. has been shown play significant role in protective humoral immunity many mi...

A human herpesvirus 7 (HHV-7) indirect immunofluorescence antibody avidity test was developed and used with an existing human herpesvirus 6 (HHV-6) antibody avidity test to detect and distinguish low-avidity antibodies to HHV-6 and HHV-7 and hence the respective primary infections. With sera from 269 British children aged 0 to 179 weeks, the tests showed that most (10 of 98 serum samples [13%])...

Objective: To evaluate avidity of IgG anti-b2-glycoprotein I antibodies (anti-b2-GPI) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in relation to thrombosis, and to demonstrate a possible affinity maturation of IgG anti-b2-GPI during the disease course. Methods: 64 sera from 32 patients (18 with primary or secondary APS, 14 with SLE without APS) and th...

OBJECTIVE Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) and are present years before the onset of symptoms. The avidity of autoantibodies can have a strong impact on their effector potency. This study was undertaken to analyze the avidity of ACPAs in serum samples obtained from ACPA-positive healthy individuals (predisease), patients with early ...