Intrinsic buccal muscle 5 (I5) in Aplysia is innervated by 2 motor neurons (termed B15 and B16). In addition to the classical transmitter ACh, B15 also contains the 2 neuropeptides SCPA and SCPB. In a previous study, we demonstrated that the SCPs were released from the terminals of B15 in the I5 muscle and that this release was sufficient to raise cAMP levels in I5 muscle fibers. Significant pe...

We have investigated the release of two peptide cotransmitters from the terminals of a cholinergic motor neuron in Aplysia. Identified motor neuron B15 synthesizes the two small cardioactive peptides (SCP) A and B in addition to acetylcholine. A symmetrical pair of B15 neurons innervate symmetrical buccal muscles, termed I5, which are involved in generating biting movements. The amplitude of I5...

We examined the effects of 3 neuropeptides and the bioactive amine 5-HT on identified motoneurons (B15 and B16) and interneurons (B4, B5) involved in the control of feeding behavior in Aplysia californica. The application of egg-laying hormone (ELH), small cardioactive peptide b (SCPb), and 5-HT elicits distinct patterns of synaptically induced bursting in the neurons, while PheMetArgPheamide (...

1. The presence of autoantibodies and the histocompatibility leucocyte antigen (HLA) antigen B15 was studied in relation to vascular complications (WHO III) in 148 patients with essential hypertension. 2. Nine of 36 patients with WHO stage III hypertension had autoantibodies, compared with seven out of 78 normotensive controls. 3. The frequency of B15 was 36.1% in hypertensive patients with sta...

Katrina Samperi School of Computer Science The University of Birmingham Birmingham, B15 2TT UK www.cs.bham.ac.uk/~kxs401 [email protected] Russell Beale School of Computer Science The University of Birmingham Birmingham, B15 2TT UK www.cs.bham.ac.uk/~rxb [email protected] Nick Hawes School of Computer Science The University of Birmingham Birmingham, B15 2TT UK www.cs.bham.ac.uk/~nah n...

1 Physical Sciences of Imaging in the Biomedical Sciences (PSIBS) doctoral training centre, University of Birmingham Edgbaston Birmingham, B15 2TT, UK. 2 School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. 3 School of Computer Science, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. * Corresponding authors: Joshua Z. Rappoport 2 , j.rappoport@bham....

The chicken major histocompatibility complex (MHC) has strong genetic associations with resistance and susceptibility to certain infectious pathogens. The cell surface expression level of MHC class I molecules varies as much as 10-fold between chicken haplotypes and is inversely correlated with diversity of peptide repertoire and with resistance to Marek's disease caused by an oncogenic herpesv...

1 Rail Research UK Gisbert Kapp Building The University of Birmingham Edgbaston, Birmingham B15 2TT, UK [email protected] 2 Railways Group Department of Civil Engineering School of Engineering The University of Birmingham Edgbaston, Birmingham B15 2TT, UK [email protected] 3 The Centre of Excellence for Research in Computational Intelligence and Applications (CERCIA) School of Computer...

During the past several years, a great furor has arisen over the promotion and sale of pangamic acid also known as Vitamin B15. This was stimulated to some extent by an article in New York magazine (Nobile, 1978) extolling this "vitamin", resulting in near exhaustion of supplies in local retail outlets, a phenomenon which eventually spread to other areas of the country. This article presents so...