There is a lot of debate on the relationship between vitamin D receptor polymorphisms and risk of breast cancer. Herein, we quantitatively analyzed the published case-control studies on this relationship by meta- analysis, performing a bibliographic search from Pubmed and CNKI up to July 31, 2013. The included case- control studies for Fok1, Bsm1, Taq1, Apa1, Cdx2 and Poly-A were 16, 19, 20, 10...

BSM1 gene encodes for bovine submaxillary mucin, which is a member of a group of macromolecular glycoproteins present in mucous secretions of mammalian respiratory, gastrointestinal, and urogenital tracts (Roussel et al., 1988). The central domain of the BSM1 gene consists of approximately 55 tandem repeats of 329 amino acids and shows high peptide sequence similarity with porcine and ovine sub...

BACKGROUND In recent years, the relevance of vitamin D receptor (VDR) gene restriction fragment length polymorphisms for various types of cancer has been investigated by a great number of studies. It has been hypothesized that VDR polymorphisms may influence both the risk of cancer occurrence and prognosis. However, studies investigating the associations between specific VDR polymorphisms and c...

There have been a few epidemiological studies reporting VDR polymorphisms including Fok1, Bsm1, Apa1 and Taq1with breast cancer incidence and therefore risk. The results however are controversial, often due to smaller sample size. Concerning most of the studies were performed on Caucasian women, we conducted this comprehensive meta-analysis encompassing 38,151 cases and 47,546 controls (Fok1: 1...

BACKGROUND Although the association between lead and cardiovascular disease is well established, potential mechanisms are still poorly understood. Calcium metabolism plays a role in lead toxicity and thus, vitamin D receptor (VDR) polymorphisms have been suggested to modulate the association between lead and health outcomes. We investigated effect modification by VDR genetic polymorphisms in th...

In this paper, a joint environmental and economic analysis of different Wastewater Treatment Plant (WWTP) control strategies is carried out. The assessment is based on the application of the Life Cycle Assessment (LCA) as a method to evaluate the environmental impact and the Benchmark Simulation Model No. 1 (BSM1). The BSM1 is taken as the benchmark scenario used to implement the control strate...

Biological and epidemiologic data suggest that vitamin D levels may influence breast cancer development. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D and additionally interacts with other cell-signaling pathways that influence cancer development. Because functional data exist on FOK1 and previous studies have suggested a relation between BSM1 and brea...

Inherited variants of the vitamin D receptor (VDR) gene may influence cancer risk by altering the effect of vitamin D on cell growth and homeostasis. Studies have examined genotypes for common VDR polymorphisms, including a single nucleotide polymorphism (SNP) detected by Bsm1, a polyadenosine [poly(A)] repeat polymorphism, and a SNP detected by Fok1, as candidates for susceptibility to cancer,...

Currently, energy and environmental efficiency are critical aspects in wastewater treatment plants (WWTPs). In fact, WWTPs are significant energy consumers, especially in the active sludge process (ASP) for the N-ammonia removal. In this paper, we face the challenge of simultaneously improving the economic and environmental performance by using a reinforcement learning approach. This approach i...

A benchmark simulation model for membrane bioreactors (BSM-MBR) was developed to evaluate operational and control strategies in terms of effluent quality and operational costs. The configuration of the existing BSM1 for conventional wastewater treatment plants was adapted using reactor volumes, pumped sludge flows and membrane filtration for the water-sludge separation. The BSM1 performance cri...