Immunotherapy with Bacillus Calmette-Guérin is widely used for treatment and prophylaxis of superficial urothelial cancer. Complications associated with Bacillus Calmette-Guérin treatment are common. The authors describe a case of granulomatous inflammation of the penis associated with intravesical Bacillus Calmette-Guérin therapy, presenting with multiple erythematous and painless nodules loca...

the aim of this investigation was to improve the storage stability and survival rate of intravesical bcg product, manufactured with an attenuated strain of mycobacterium bovis (pasteur strain 1173p2 of bcg) in the presence of sodium glutamate. formulations with various concentrations of trehalose (a known protectant) were developed as liquid and lyophilized forms. formulations were evaluated by...

BACKGROUND The Bacillus Calmette-Guérin vaccine, which is used for the prevention of tuberculosis, is considered protective against the severe forms of childhood tuberculosis. However, some serious adverse reactions including osteitis of the long bones can occur. CASE PRESENTATION We report a case of an 18-month-old Sudanese girl who presented at the age of 3 months with swelling of her left ...

PURPOSE We systematically review the benefits and harms of intravesical therapies for nonmuscle invasive bladder cancer. MATERIALS AND METHODS Systematic literature searches were performed of Ovid MEDLINE (January 1990 through February 2016), the Cochrane databases and reference lists. Randomized and quasi-randomized trials of intravesical bacillus Calmette-Guérin, mitomycin C, gemcitabine, t...

Treatment of C57BL/6 mice with Bacillus Calmette-Guérin i.p. 8 days prior to the induction of leukopenia by cyclophosphamide (300 mg/kg i.p.) significantly (p less than 0.002) increased peripheral granulocyte counts on each day during the recovery from leukopenia. The recovery of lymphocyte counts was unaffected by Bacillus Calmette-Guérin treatment. Further experiments indicated that the accel...

We report an unusual complication of intravesical Bacillus Calmette-Guérin therapy for superficial bladder cancer, namely, retention of urine secondary to prostatic Bacillus Calmette-Guérin infection and abscess. A summary of the literature together with a review of its management is discussed.

background: bacillus calmette-guérin (bcg) vaccination is recommended for newborn infants worldwide to prevent tuberculosis. however, complications do occur inevitably in a very low rate, among which the most serious is disseminated disease. the disseminated bacillus calmette–guérin disease is a rare disease with high fatality, and can be seen among persons with an underlying immunodeficiency. ...

phosphodiesterases  (pde)  hydrolyse intracellular camp  and  cgmp  to  inactive  5’ monophosphates. decreased level of camp is involved in the pathogenesis of asthma. we and others have shown that phosphodiesterases were upregulated in the lung of allergic rats, and bacilli calmette-guérin (bcg) induced the production of camp in vitro. however, it is unclear how bcg’s effect asthma and whether...

introduction bacillus calmette-guérin (bcg) vaccine, a live attenuated mycobacterium bovis strain, is administrated to all newborn infants in endemic regions according to the current world health organization (who) recommendation. case presentation we report a 10-month-boy who was a known case of severe combined immunodeficiency (scid) admitted with multi-focal fusiform painful swelling in his ...