This study aimed to investigate the effects of flavonoid glycoside on mitochondrial dysfunction and inflammatory oxidative stress in macular degeneration. Sixty specific-pathogen-free male Bagg Albino mice were randomly divided into control, model glycoside. Human retinal pigment epithelium cells ARPE-19 cultured treated with dimethyl sulfoxide, sodium iodate respectively. Fundus fluorescein an...

The risk of spread of malignant tumors follow ing biopsy has been the subject of numerous in vestigations (2), while only a few workers have been concerned with this risk following local roent gen irradiation. Yamamoto (4) found an increased frequency of metastasis to bone following local roentgen irradiation of the Kato rabbit sarcoma with doses of 600-1,800 r. Kaplan and Murphy (3) investigat...

The etiological agent of the acute hepatitis encountered in weanling mice of the Princeton strain is a virus found in the liver, spleen, kidneys, heart's blood, urine, and intestinal contents of experimentally infected animals. Older Princeton mice and weanlings from four other strains (Swiss, Webster's BSVS, C albino) and Bagg) proved to be less susceptible than Princeton weanlings. The virus ...

This study investigated the effect of Chondria crassicaulis ethanol extract on degranulation rat basophilic leukemia-2H3 cells and 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in Bagg Albino/c mice. General properties (proximate analysis, total phenol flavonoid) were measured; moreover, beta-hexosaminidase release cytotoxicity cells, severity dermatitis, production cytok...

Relaxin, when administered to mice pretreated with estrogen, induces a transformation of the joint cartilage into ligamentous tissue. This transformation , which results in an increased distance between the pubic bones that border the joint, is similar to that occurring during normal pregnancy."'2 The increase in interpubic distance following relaxin treatment has been the chief criterion used ...

There are several studies concerned with the elucidation of the genetics of transplantability of neoplasms in mice (12, 33). The results have varied with the inbred stocks used, but one fundamental question is raised by all: Is the transplantation pattern of neoplastic cells different from that of normal cells ? The earliest investigations on transplantation of neoplastic and normal tissues wer...

Evidence has previously been submitted in favor of the theory that susceptibility to spontaneous tumors of various types is inherited. The question arose whether susceptibility to tumors induced by tar could be shown to be hereditary by experimenting with the same strains of mice which had already been shown to differ significantly in respect to their spontaneous tumor rates. Two strains of mic...

An hepatic disease caused by a filterable agent carried in leukemic mice is described. Ordinarily the virus remains latent and asymptomatic. If, however, the mice are treated with urethane or methylformamide before and after virus inoculation, the disease becomes manifest and is characterized by extremely marked liver necrosis. Infant mice, a large percentage of weanlings, and adult Bagg albino...