During recent years, the silicon organic-inorganic compounds play the key role in medicinal chemistry and pharmaceutical industry. This is because of their similar chemical properties with carbon compounds. The second reason is related to their easy transfer from the cell membranes. So, molecular simulation and study the properties of novel organosilicon compounds can be more important. From th...

We performed laboratory experiments to study the photochemical evolution induced by long-UV irradiation of benzene ices in Titan's atmosphere. The aim this was investigate whether photo-processed could lead formation aerosols analogs those observed stratosphere. Prior that, spectroscopic properties amorphous and crystalline were studied as a function temperature, using infrared spectroscopy. UV...

The present study examined the biodegradation rate of benzene vapors in a two phase stirred tank bioreactor by a bacterial consortium obtained from wastewater of an oil industry refinery house. Initially, the ability of the microbial consortium for degrading benzene was evaluated before running the bioreactor. The gaseous samples from inlet and outlet of bioreactor were directly injected into a...

Three juvenile hormone analogs were found to be in vitro inhibitors of rat liver microsomal oxidases. Aniline hydroxylase reactions gave apparent inhibition constants of 8 X 10-5 M and 1.4 X 10 4 M for ( E ) -4[( 6,7 -epoxy-3,7 dimethyl2monenyl)oxy] 1,2(methylenedioxy) benzene and (E) 4 [(6,7 epoxy 3 ethyl 7 methyl 2 noneny1)oxyl 1,2 (methylenedioxy)benzene, respectively. (E)-6,7-Epoxy-l-(p-eth...

The cleavage of silicon–hydrogen bonds to generate silicon-containing metal complexes has played an essential role in the preparation organosilicon compounds. Herein, we report reaction cyclopentadienone iridium complex 1 with hydrosilanes afford hydroxycyclopentadienyl silyl 4 via umpolung Si–H bond. nucleophilicity Ir–Si bond resulting was demonstrated allyl halide and ethyl acrylate. Further...

We simulated the docking of the tertiary structure of mushroom tyrosinase with our compounds. From the structure-tyrosinase inhibitory activity relationship, it is notable that compounds 4, 8 and 11 showed similar or better activity rates than kojic acid which was used as a positive control. Compounds 17, 21, and 23 among benzene analogs that possess the same substituent showed significantly lo...

Benzene and its substituted analogs are considered hazardous because of their high risk to public health and the environment. Porous carbon materials are widely studied for their potential ability to act as a filter of carcinogenic materials. This study uses firstprinciples calculations to explore the selective adsorption of benzene and benzenes with substituents varying in electronegativity an...

1,2-Bis(indol-2-yl)benzene was prepared and found to serve as an effective bidentate ligand to form stable silicon complexes bearing two N-Si bonds. These complexes take boat-shaped 2,7-diaza-1-silepin structures, which undergo a butterfly-like conformational motion whose activation barriers were determined by shape analysis of variable-temperature (1)H NMR spectra. These silicon complexes exhi...

Transmembrane domain 6 of the muscarinic acetylcholine (ACh) receptors is important in ligand binding and in the conformational transitions of the receptor but the roles of individual residues are poorly understood. We have carried out a systematic alanine-scanning mutagenesis study on residues Tyr381 to Val387 within the binding domain of the M(1) muscarinic ACh receptor. The seven mutations w...