Contents I The basis of the bioheat transfer theory 1 1 INTRODUCTION: Essentials of the description of transport phenomena in highly heterogeneous media. What the bioheat transfer problem is 3 2 Mean field approach to the bioheat transfer problem 10 2.1 Modern models for heat transfer in living tissue. .

Bioheat transfer is the study of the transport of thermal energy in living systems. Because biochemical processes are temperature dependent, heat transfer plays a major role in living systems. Also, because the mass transport of blood through tissue causes a consequent thermal energy transfer, bioheat transfer methods are applicable for diagnostic and therapeutic applications involving either m...

Heat transfer in living tissues is a complicated process because it involves a combination of thermal conduction in tissues, convection and perfusion of blood, and metabolic heat production. Over the years, several mathematical models have been developed to describe heat transfer within living biological tissues. These models have been widely used in the analysis of hyperthermia in cancer treat...

Theoretical analysis on the bioheat transfer process has been an extremely important issue in a wide variety of bioengineering situations such as cancer hyperthermia, burn injury evaluation, brain hypothermia, disease diagnostics, thermal comfort analysis, cryosurgery and cryopreservation etc. In this chapter, the theoretical strategies towards exactly solving the three-dimensional (3-D) biohea...

In this work, a method for estimating the space-dependent perfusion coefficient parameter in a 2D bioheat transfer model is presented. In the method, the bioheat transfer model is transformed into a time-dependent semidiscrete system of ordinary differential equations involving perfusion coefficient values as parameters, and the estimation problem is solved through a nonlinear least squares tec...

The bioheat transfer simulation is undoubtedly the foundation for developing computerized tools for cryosurgery planning and analysis. While a large variety of techniques for bioheat transfer simulations are available in the literature of the past several decades, it is only their integration with clinical criteria and constraints which can make computerized planning a practical reality. This b...

The human thermal comfort is the state of mind, which affected not only by physical and body’s internal physiological phenomena but also clothing properties such as resistance clothing, insulation, area factor, air relative humidity. In this work, we extend one-dimensional Pennes’ bioheat transfer equation adding protective layer. transient temperature profile with layer at different time steps...

As a part of ongoing efforts to develop computerized planning tools for cryosurgery, the current study focuses on developing an efficient numerical technique for bioheat transfer simulations. Our long-term goal is to develop a planning tool for cryosurgery that takes a 3D reconstruction of a target region, and suggests the best cryoprobe layout. Toward that goal, a planning algorithm, termed "f...

This paper deals with the study of fractional bioheat equation for heat transfer in skin tissue with sinusoidal heat flux condition on skin surface. Numerical solution is obtained by implicit finite difference method. The effect of anomalous diffusion in skin tissue has been studied with different frequency and blood perfusion respectively, the temperature profile are obtained for different ord...

Over the past 100 years, the understanding of thermal and mechanical properties of human tissues and physics that governs biological processes has been greatly advanced by the utilization of fundamental engineering principles in the analysis of many heat and mass transport applications in biology and medicine. During the past two decades, there has been an increasingly intense interest in biohe...