biomimetic method was used to apply hydroxyapatite (ha) coating onto ti6al4v cylinders. this process is a physicochemical method in which a substrate is soaked in a solution simulating the physiological conditions, for a period of time enough to form a desirable layer of the calcium phosphate on the substrate. in the present study, specimens were soaked in 5, 10 m solutions of naoh at temperatu...

Novel scaffolds composed of poly(L-lactic acid) (PLLA) skeleton covered with bonelike apatite or apatite/collagen composite were produced via a combined phase-separation technique and an accelerated biomimetic coating process. Saos-2 osteoblast-like cells were used to evaluate the cellular behaviors on these biomimetic coatings. Cell morphologies on the surfaces of PLLA scaffolds, PLLA scaffold...

Calcium phosphate coating (CaP) has been employed for protein delivery, but the typical direct protein adsorption on the coating led to low incorporation content and fast release of the protein from the coating. By using bovine serum albumin (BSA) as a model protein, rapid biomimetic co-precipitation between calcium phosphate and BSA was employed to control the distribution of BSA within calciu...

Microstructural characteristics and biocompatibility of a Type-B carbonated hydroxyapatite (HA) coating prepared on NiTi SMA by biomimetic deposition were characterized using XRD, SEM, XPS, FTIR and in vitro studies including hemolysis test, MTT cytotoxicity test and fibroblasts cytocompatibility test. It is found CO(3)(2-) groups were present as substitution of PO(4)(3-) anions in HA crystal l...

Dental implant failure often occurs due to oral bacterial infection. The aim of this study was to demonstrate that antibiotic efficacy could be enhanced with modified titanium. First, the titanium was modified by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersi...

Introduction: The calcium phosphate ceramics, in particular hydroxyapatite ( HA), has shown to be capable of conducting bone formation and forming a chemical bond to bone. Because of this osteoconductivity, HA ceramic has been applied in joint reconstruction in the form of coating on joint implants such as hip stems by plasma spraying technique. Direct bone apposition has been repeatedly demons...

The repair of critical-sized bone defects is still challenging in the fields of implantology, maxillofacial surgery and orthopaedics. Current therapies such as autografts and allografts are associated with various limitations. Cytokine-based bone tissue engineering has been attracting increasing attention. Bone-inducing agents have been locally injected to stimulate the native bone-formation ac...

The next great wave of innovation and development for implantable medical devices focuses on surface engineering. This would enhance their performance, restore lost functions and ultimately reduce pain. Biomimetic coating is a promising approach, used in that concern. In the present work, an attempt was made to develop the function of the biomimetic coating rather than the classical biocompatib...

Biomimetic calcium phosphate (CaP) coating has been used successfully for protein delivery, but the release of protein from CaP coating is mainly dependent on the limited dissolution of the CaP coating and the passive diffusion of the protein in the CaP coating. In the present work, our aim is to improve the release behavior of protein from CaP coating and make it more controllable. By using bo...

The purpose of this work is to improve the cytocompatibility and corrosion resistance of magnesium alloy in the hope of preparing a biodegradable medical material. The aminated hydroxyethyl cellulose-induced biomimetic hydroxyapatite coating was successfully prepared on AZ31 magnesium alloy surface with a sol-gel spin coating method and biomimetic mineralization. Potentiodynamic polarization te...